2. Anti-infection
  3. HCV HIV
  4. LJ001

LJ001 

目录号: HY-16957 纯度: 98.09%
COA 产品使用指南

摩尔计算器

LJ001 是一种广谱的具有口服活性的抗病毒活性分子。LJ001 通过与病毒膜结合发挥抗病毒活性。LJ001 抑制 TGEV 和 PDCoV 感染。LJ001 降低 TGEV N 和 PDCoV N 蛋白的表达。

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LJ001 Chemical Structure

LJ001 Chemical Structure

CAS No. : 851305-26-5

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
1 mg ￥909
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5 mg ￥2000
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10 mg ￥3200
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25 mg ￥6500
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LJ001 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LJ001 is a broad-spectrum and orally active antiviral agent. LJ001 exerts antiviral activities by binding to viral membranes. LJ001 inhibits TGEV and PDCoV infection. LJ001 decreases TGEV N and PDCoV N-protein expression[1][2].

体外研究
(In Vitro)

LJ001 (0.782- 200 μM; 24 h) 没有显着的细胞毒性，对 ST 细胞的 CC50 值为 146.4 μM[1]。
LJ001 (12.5 µM; 12, 24 h) 抑制传染性胃肠炎病毒 (TGEV) 和猪三角洲冠状病毒 (PDCoV) 感染[1]。
LJ001 (12.5 µM; 1, 6,12, 24 h) 降低 ST 细胞中的 TGEV 和 PDCoV 基因 mRNA 表达[1]。
LJ001 可以抑制一些包膜病毒的进入和传播，包括人类免疫缺陷病毒(HIV)、丙型肝炎病毒(HCV)、流感病毒、埃博拉病毒、沙粒病毒和痘病毒[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LJ001 相关抗体:

Cell Viability Assay[1]

Cell Line: ST cells
Concentration: 0.782, 1.563, 3.125, 6.25, 12.5, 25, 50, 100, 200 μM
Incubation Time: 24 h
Result: Showed slight cytotoxicity with a CC50 value of 146.4 μM.

Western Blot Analysis[1]

Cell Line: ST cells
Concentration: 12.5 µM
Incubation Time: 12, 24 h
Result: Decreased the expression of TGEV N protein and PDCoV N-protein at 24 h and markedly reduced TCID50 titers at 12 and 24 h.

RT-PCR[1]

Cell Line: ST cells
Concentration: 12.5 µM
Incubation Time: 1, 6, 12, 24 h
Result: Inhibited TGEV and PDCoV gene mRNA expression in a time-dependent manner.
体内研究
(In Vivo)

LJ001 (20, 50 mg/kg; oral gavage or i.p.; daily for 7 days) 在小鼠中未显示出毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice[2]
Dosage: 20, 50 mg/kg
Administration: Oral gavage or i.p.; daily for 7 days
Result: Revealed no abnormalities except a slight elevation in serum cholesterol levels in the treated vs. vehicle control group.
分子量

327.42

性状

固体

Formula

C17H13NO2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

LJ001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LJ001851305-26-5LJ 001LJ-001HCVHIVHepatitis C virusHuman immunodeficiency virusno toxicityTGEVPDCoVST cellsviral membranesorally activeInhibitorinhibitorinhibit

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