1. MAPK/ERK Pathway
  2. p38 MAPK
  3. LNSMGQD

LNSMGQD 是一种靶向桥粒芯糖蛋白 DSG1 和桥粒芯糖蛋白 DSG3 黏附界面的肽,可干扰 DSG 反式相互作用的单肽 (SP) 的组成部分。LNSMGQD 通过与 DSGs 结合,阻止自身抗体诱导的 DSG 反式相互作用丧失,抑制 p38 MAPK 激活和角蛋白丝回缩。LNSMGQD 可用于寻常型天疱疮等自身免疫性皮肤病的研究。

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Custom Peptide Synthesis

LNSMGQD

LNSMGQD Chemical Structure

CAS No. : 1152066-26-6

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规格 价格 是否有货 数量
5 mg ¥810
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10 mg ¥1305
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25 mg ¥2430
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50 mg ¥3600
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查看 p38 MAPK 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LNSMGQD is a peptide that targets the adhesion interface of desmoglein DSG1 and DSG3, and interferes with the DSG trans-interaction single peptide (SP) component. LNSMGQD blocks autoantibody-induced loss of DSG trans-interactions by binding to DSGs, inhibiting p38 MAPK activation and keratin filament retraction. LNSMGQD can be used to study autoimmune skin diseases such as pemphigus vulgaris[1].

分子量

763.82

Formula

C29H49N9O13S

CAS 号
性状

固体

颜色

White to off-white

Sequence

Leu-Asn-Ser-Met-Gly-Gln-Asp

Sequence Shortening

LNSMGQD

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LNSMGQD
目录号:
HY-P11017
需求量: