2. Epigenetics Metabolic Enzyme/Protease
  3. Epigenetic Reader Domain E1/E2/E3 Enzyme
  4. LO-3-61

LO-3-61 是一种 JQ-1 (HY-13030) 类似物，带有截短的富马酰胺基团，属于具有 PROTAC (蛋白降解靶向嵌合体) 特性的 BRD4 降解剂。LO-3-61 通过 CUL4DCAF16 依赖性途径降解细胞中 BRD4 的长、短两种亚型。LO-3-61 在 MDA-MB-231 细胞中显示对 BRD3 和 BRD4 降解的选择性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LO-3-61

LO-3-61 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

LO-3-61 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LO-3-61, a JQ-1 (HY-13030) analog bearing a truncated fumaramide handle, is a PROTAC (proteolysis-targeting chimeras)-like BRD4 degrader. LO-3-61 degrades both the long and short isoforms of BRD4 CUL4DcAr16-dependently in cells. LO-3-61 shows selectivity for BRD3 and BRD4 degradation in MDA-MB-231 cells[1].

体外研究
(In Vitro)

LO-3-61 (0.1-1 μM, 24 h) 在 HEK293T 细胞 (WT, CUL4DCAF16 C173S, CUL4DCAF16 C178S) 中通过蛋白酶体介导 BRD4 的降解，这一效应在 DCAF16 敲除细胞中可被抑制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LO-3-61 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293T cells (WT, CUL4DCAF16 C173S, CUL4DCAF16 C178S, DCAF16 KO)
Concentration: 0.1, 1 μM
Incubation Time: 24 h
Result: Degraded BRD4 when BTZ (1 μM) for 1 h prior to treatment in HEK293T cells (WT, CUL4DCAF16 C173S, CUL4DCAF16 C178S).
Did not affect the degradation of BRD4 in DCAF16 KO cells.
分子量

677.60

Formula

C32H30Cl2N8O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LO-3-61 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LO-3-61Epigenetic Reader DomainE1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseDCAF16HEK293T cellsBRD4Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
LO-3-61
目录号：
HY-175179
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z