2. GPCR/G Protein
  3. LPL Receptor
  4. Lpathomab

Lpathomab  (Synonyms: LT3015; LT-3000)

目录号: HY-P991310
技术支持

Lpathomab (LT3015; LT-3000) 是一种靶向 LPA 的人类 IgG1 单克隆抗体 (mAb)。Lpathomab 降低 SKOV3 细胞中 IL-8 和 IL-6 细胞因子的释放，并阻断 LPA 触发的肿瘤细胞迁移。Lpathomab 在 Matrigel 栓和 CNV 模型中减少新生血管形成。Lpathomab 在 CCI 小鼠模型中可抑制脑损伤。Lpathomab 可用于脑损伤、卵巢癌、糖尿病性神经病变和脊髓损伤的研究。推荐同型对照：Human IgG1 kappa，Isotype Control (HY-P99001)。

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Lpathomab Chemical Structure

Lpathomab Chemical Structure

CAS No. : 1253114-37-2

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规格 是否有货
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Customer Review

Lpathomab 相关抗体

Top Publications Citing Use of Products

查看 LPL Receptor 亚型特异性产品:

查看所有亚型
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and blocks LPA-triggered tumor cell migration. Lpathomab reduces neovascularization in Matrigel plug and CNV models. Lpathomab inhibits brain injury in the CCI mouse model. Lpathomab can be used in the study of brain injury, ovarian cancer, diabetic neuropathy, and spinal cord injury. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2].

应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
同用名

LT3015; LT-3000

CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lpathomab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lpathomab1253114-37-2LT3015 LT-3000LT 3015LT-3015LT3000LT 3000LT-3000LPL ReceptorLysophospholipid ReceptorLPAbrain injuryovarian cancerdiabetic neuropathyspinal cord injurySKOV3 IL-8IL-6B16-F10Inhibitorinhibitorinhibit

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