2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Lupartumab Amadotin

Lupartumab Amadotin  (Synonyms: BAY 1129980; Anti-C4.4a antibody-drug conjugates)

目录号: HY-P99719 纯度: 99.61%
COA 产品使用指南 技术支持

Lupartumab Amadotin (BAY 1129980) 是一种由全人源 C4.4A (LYPD3) 靶向单抗 (BAY 1135626) (HY-147281) 通过不可切割的烷基肼连接物与一种新型、高效的微管破坏细胞毒药物 auristatin 衍生物结合的抗体-药物偶联物 (ADC)。Lupartumab Amadotin 可用于非小细胞肺癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lupartumab Amadotin

Lupartumab Amadotin Chemical Structure

CAS No. : 1640972-00-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥4140
In-stock
5 mg 现货 询价
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Lupartumab Amadotin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lupartumab Amadotin (BAY 1129980) is an antibody–drug conjugate (ADC) consisting of a fully human C4.4A (LYPD3)-targeting mAb (BAY 1135626) (HY-147281) conjugated to a novel, highly potent derivative of the microtubule-disrupting cytotoxic drug auristatin via a noncleavable alkyl hydrazide linker. Lupartumab Amadotin can be used for the research of non-small cell lung cancer[1].

IC50 & Target

human C4.4A[1]
体外研究
(In Vitro)

Lupartumab Amadotin (BAY 1129980; 0-2 nM; 72 h) 在内源性表达 C4.4A 的细胞系中显示出强大的抗增殖功效，并抑制 C4.4A 转染的 A549 肺癌细胞的增殖，与非靶向对照 ADC 相比显示出选择性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lupartumab Amadotin 相关抗体:

Cell Viability Assay[1]

Cell Line: hC4.4A:A549, mock:A549, NCI-H292, FaDu, NCI-H322, SCaBER and SCC-4 cells
Concentration: 0-2 nM
Incubation Time: 72 h
Result: High potency at subnanomolar range (IC50=0.05 nM) was observed in hC4.4A:A549 lung cancer cells, a remarkable selectivity (over 1,000-fold) compared with mock:A549 cells was observed. Showed high potency with IC50s at single- to double-digit nanomolar range and even at subnanomolar range (IC50 of 0.6 nM) in NCI-H292 lung cancer cell line.
体内研究
(In Vivo)

Lupartumab Amadotin (BAY 1129980; 1.9-15 mg/kg; i.v.; Q4D×3) 在 C4.4A 阳性的 NCI-H292 和 NCI-H322 NSCLC 异种移植模型中显示出抗肿瘤效果[1]。
Lupartumab Amadotin (BAY 1129980; 7.5 and 15 mg/kg; i.v.; Q4D×3) 显示在 NSCLC 患者源性异种移植 (PDX) 模型中 C4.4A 靶点依赖的抗肿瘤疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI nu/nu mice, C4.4A-positive NCI-H292 human NSCLC xenograft model[1]
Dosage: 1.9, 3.75, 7.5 and 15 mg/kg
Administration: IV, Q4D×3
Result: Halted tumor growth dose dependently with a minimum effective dose (MED) of 1.9 mg/kg. The first treatment cycle with 15 mg/kg drug (Q4D×3) resulted in a marked delay of tumor growth with a significantly reduced tumor volume, as compared to vehicle, Cisplatin (HY-17394), or control ADC.
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

阿汀-鲁帕妥单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lupartumab Amadotin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lupartumab Amadotin1640972-00-4BAY 1129980 Anti-C4.4a antibody-drug conjugates阿汀-鲁帕妥单抗BAY1129980BAY-1129980Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesnon-small cell lung cancerA549NCI-H292FaDuNCI-H322SCaBERSCC-4NMRI nu/nu miceNSCLCInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Lupartumab Amadotin
目录号：
HY-P99719
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z