2. PI3K/Akt/mTOR
  3. mTOR
  4. M-1111

M-1111 是一种 Rapa-Link 抑制剂。M-1111 由 Rapamycin (HY-10219) 和活性位点 mTOR 抑制剂共价连接而成。M-1111 对 mTORC1 信号通路 (pS6 和 p4E-BP1) 具有强抑制活性。M-1111 对多种癌细胞具有纳摩尔级别的抑制活性。M-1111 完全抑制 p4E-BP1，不抑制 pAkt S473。M-1111 可用于研究肝癌、肾癌、结直肠癌。

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M-1111

M-1111 Chemical Structure

CAS No. : 1887095-86-4

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M-1111 相关抗体

Top Publications Citing Use of Products

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

M-1111 is a Rapa-Link inhibitor. M-1111 is covalently linked by Rapamycin (HY-10219) and an inhibitor of the active site mTOR. M-1111 has strong inhibitory activity on the mTORC1 signaling pathway (pS6 and p4E-BP1). M-1111 has nanomolar-level inhibitory activity against various cancer cells. M-1111 completely inhibits p4E-BP1 without inhibiting pAkt S473. M-1111 can be used for research on liver cancer, kidney cancer, and colorectal cancer[1].

IC50 & Target[1]

mTORC1

 

分子量

1740.08

Formula

C89H134N12O23
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

M-1111 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M-11111887095-86-4M1111M 1111mTORMammalian target of RapamycinmTORC1 inhibitorHybrid compoundRapa-LinkRapamycin analogActive-site mTOR inhibitorMechanistic target of rapamycinDrug discoveryCancer therapySelective inhibitionPharmaceutical compositionInhibitorinhibitorinhibit

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