1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. m-PEG10-alcohol

m-PEG10-alcohol (Synonyms: Decaethylene glycol monomethyl ether)

目录号: HY-141218
产品使用指南

m-PEG10-alcohol (Decaethylene glycol monomethyl ether) 是一种不可降解 (non-cleavable) 的含 10 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。m-PEG10-alcohol 还是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。

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m-PEG10-alcohol Chemical Structure

m-PEG10-alcohol Chemical Structure

CAS No. : 27425-92-9

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Description

m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

Non-cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight

472.57

Formula

C₂₁H₄₄O₁₁

CAS No.

27425-92-9

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

m-PEG10-alcoholDecaethylene glycol monomethyl etherADC LinkerPROTAC LinkerAntibody-drug conjugates linkerPEGADCnon-cleavablelinkerPROTACInhibitorinhibitorinhibit

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产品名称:
m-PEG10-alcohol
目录号:
HY-141218
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