2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-A/B-IN-5

MAO-A/B-IN-5 是一种口服活性的 MAO-A (IC50 = 73.88 μM) 和 MAO-B (IC50 = 91.08 μM) 抑制剂。MAO-A/B-IN-5 逆转 Sodium nitroprusside (SNP) (HY-B0564) 诱导的大脑脂质过氧化 (IC50 = 130.2 μM) 和蛋白质羰基化作用 (IC50 = 229.8 μM)。MAO-A/B-IN-5 在小鼠中显示出剂量依赖和时间依赖的抗抑郁样疗效。MAO-A/B-IN-5 可用于抑郁症研究。

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MAO-A/B-IN-5

MAO-A/B-IN-5 Chemical Structure

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MAO-A/B-IN-5 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-A/B-IN-5 is an orally active MAO-A (IC50 = 73.88 μM) and MAO-B (IC50 = 91.08 μM) inhibitor. MAO-A/B-IN-5 reverses Sodium nitroprusside (SNP) (HY-B0564)-induced cerebral lipid peroxidation (IC50 = 130.2 μM) and protein carbonylation (IC50 = 229.8 μM). MAO-A/B-IN-5 shows dose-dependent and time-dependent antidepressant-like efficacy in mice. MAO-A/B-IN-5 can be used for the study of depressive disorder[1].

IC50 & Target[1]

MAO-A

73.88 μM (IC50)

MAO-B

91.08 μM (IC50)

体外研究
(In Vitro)

MAO-A/B-IN-5 (Compound 3B) (25-200 μM) 显著抑制小鼠脑组织中的 MAO-A 和 MAO-B 活性，其 IC50 值分别为 MAO-A 73.88 μM 和 MAO-B 91.08 μM[1]。
MAO-A/B-IN-5 (100-500 μM) 逆转硝普钠诱导的大脑脂质过氧化 (IC50 = 130.2 μM) 和蛋白质碳基化 (IC50 = 229.8 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-A/B-IN-5 相关抗体:
体内研究
(In Vivo)

MAO-A/B-IN-5 (Compound 3B) (0.5-5 mg/kg，灌胃给药，单次给药) 在雄性 Swiss 小鼠的悬尾实验中表现出抗抑郁样效应[1]。
MAO-A/B-IN-5 (50-300 mg/kg，灌胃给药，单次给药，观察 14 天) 在雌性 Swiss 小鼠中未引起死亡、未见明显毒性迹象，且未显著改变食物/水摄入量、体重或器官氧化损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Swiss mice (25-30 g)[1]
Dosage: 0.5, 1, 2.5, 5 mg/kg
Administration: i.g., once
Result: Demonstrated dose-dependent antidepressant-like activity in male Swiss mice (30 min post-intragastric administration), with significant effects at doses of 1, 2.5, and 5 mg/kg.
Increased latency to immobility and reduced total immobility time in TST.
分子量

461.25

Formula

C21H20BrNOSe
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-A/B-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-A/B-IN-5Monoamine OxidaseMAOMAO-A/Bdepressive disordercarbonylationlipid peroxidationInhibitorinhibitorinhibit

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