1. Academic Validation
  2. Phenylpropanoid ester from Zingiber officinale and their inhibitory effects on the production of nitric oxide

Phenylpropanoid ester from Zingiber officinale and their inhibitory effects on the production of nitric oxide

  • Arch Pharm Res. 2012 Feb;35(2):315-20. doi: 10.1007/s12272-012-0211-y.
Seong Su Hong 1 Joa Sub Oh
Affiliations

Affiliation

  • 1 Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion, Suwon 443-766, Korea.
Abstract

A new phenylpropanoid ester mixture, (E)-geranylferulic acid (1a) and (Z)-geranylferulic acid (1b), along with 13 known compounds, [6]-gingerol (2), [8]-gingerol (3), [10]-gingerdione (4), 1-dehydro-[6]-gingerdione (5), 1-dehydro-[8]-gingerdione (6), [6]-paradol (7), [8]-paradol (8), [6]-gingeroldiacetate (9), 6-hydroxy-[6]-shogaol (10), galanolactone (11), trans-®-sesquiphellandrol (12), trans-sesquipiperitol (13), and 4α,5β-dihydroxybisabola-2,10-diene (14) were isolated from ethanol extract of Zingiber officinale. Their structures were determined based on the spectroscopic (1D, 2D-NMR and MS) and chemical evidence. All of the isolates were evaluated for their potential to inhibit LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells. Compounds 1-12 were found to inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM.

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