MCPA-¹³C₈  (Synonyms: 4-Chloro-2-Methylphenoxyacetic acid-¹³C₈)

MCPA-¹³C₈ is the ¹³C-labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds^{[1][2][3][4][5][6]}.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

208.56

C¹³C₈H₉ClO₃

94-74-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Kimura O, et al. Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter. Toxicol Appl Pharmacol. 2008 Mar 15;227(3):325-30.  [Content Brief]

  [3]. Peixoto F P, et al. Toxicity of MCPA on non-green potato tuber calli. Acta Physiologiae Plantarum, 2009, 31(1): 103-109.

  [4]. Gao Y F, et al. The influence of chlorophenoxy herbicides MCPA on creeping bentgrass physiological index. Advanced Materials Research, 2012, 356: 2763-2766.

  [5]. Inomata N, et al. Effects of MCPA and other phenoxyacid compounds on hepatic xenobiotic metabolism in rats. Tohoku J Exp Med. 1991 Nov;165(3):171-82.  [Content Brief]

  [6]. van Ravenzwaay B, et al. Absorption, distribution, metabolism and excretion of 4-chloro-2-methylphenoxyacetic acid (MCPA) in rats. Food Chem Toxicol. 2004 Jan;42(1):115-25.  [Content Brief]