1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Metarrestin

Metarrestin (Synonyms: ML246)

目录号: HY-120118
产品使用指南

Metarrestin (ML246) 破坏核仁结构并抑制 RNA 聚合酶 (Pol) I 转录,部分是通过与翻译延伸因子 eEF1A2 相互作用。Metarrestin 是一种一流的核周区室抑制剂,具有良好的 PK 特性,可有效抑制转移。

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Metarrestin Chemical Structure

Metarrestin Chemical Structure

CAS No. : 1443414-10-5

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Description

Metarrestin (ML246) disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis[1][2].

IC50 & Target

RNA polymerase (Pol) I[1][2]

Molecular Weight

474.60

Formula

C₃₁H₃₀N₄O

CAS No.

1443414-10-5

SMILES

O[C@H]1CC[C@H](N(C=NC2=C3C(C4=CC=CC=C4)=C(C5=CC=CC=C5)N2CC6=CC=CC=C6)C3=N)CC1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Metarrestin
目录号:
HY-120118
需求量:

Metarrestin

Cat. No.: HY-120118