1. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related Apoptosis
  2. Antifolate DNA/RNA Synthesis ADC Cytotoxin Apoptosis
  3. Methotrexate-d3

Methotrexate-d3  (Synonyms: 甲氨蝶呤 d3)

目录号: HY-14519S
COA 产品使用指南

Methotrexate-d3 是 Methotrexate 的氘代物。Methotrexate (Amethopterin) 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate),可抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。Methotrexate也是一种免疫抑制剂和抗肿瘤剂,用于类风湿关节炎和研究多种癌症 (如急性淋巴细胞白血病)。

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Methotrexate-d<sub>3</sub> Chemical Structure

Methotrexate-d3 Chemical Structure

CAS No. : 432545-63-6

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1 mg ¥3500
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methotrexate-d3 (Amethopterin-d3) is the deuterium labeled Methotrexate. Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

457.46

Formula

C20H19D3N8O5

CAS 号
性状

固体

颜色

White to yellow

中文名称

甲氨蝶呤 d3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Methotrexate-d3
目录号:
HY-14519S
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