2. Apoptosis TGF-beta/Smad Epigenetics NF-κB Metabolic Enzyme/Protease Others
  3. Apoptosis PKC Keap1-Nrf2 Heme Oxygenase (HO) Drug Derivative
  4. MGF24

MGF24 是一种经修饰的、具有抗蛋白酶活性的 MGF 衍生物。MGF24 通过诱导血红素加氧酶-1 (HO-1) 来保护多巴胺能神经元免受 6-Hydroxydopamine (6-OHDA) (HY-113028) 诱导的细胞凋亡(apoptosis)。MGF24 激活 PKC-ε，进而激活 Nrf2，从而上调 HO-1 的表达。MGF24 具有神经保护作用，并能缩小绵羊心肌缺血模型中的心肌梗死面积。MGF24 可用于中风、神经损伤和肌萎缩侧索硬化症等神经系统疾病的研究。

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Custom Peptide Synthesis

MGF24

MGF24 Chemical Structure

CAS No. : 1611488-66-4

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MGF24 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

查看 Heme Oxygenase (HO) 亚型特异性产品:

查看所有亚型
HO-1 HO-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MGF24 is a modified protease-resistant MGF derivative. MGF24 protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA) (HY-113028)-induced apoptosis by inducing Heme oxygenase-1 (HO-1). MGF24 activates PKC-ε, which in turn activates Nrf2, up-regulating HO-1. MGF24 has neuroprotective activity and reduces myocardial infarct size in sheep models of myocardial ischemia. MGF24 can be used for neurological diseases like stroke, nerve injury and amyotrophic lateral sclerosis research[1].

分子量

2848.09

Formula

C121H195N41O39
CAS 号
Sequence

Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
Sequence Shortening

YQPPSTNKNTKSQRRKGSTFEEHK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MGF24 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MGF241611488-66-4MGF 24MGF-24ApoptosisPKCKeap1-Nrf2Heme Oxygenase (HO)Drug DerivativeProtein kinase CHeme OxygenaseDrug derivativeMGFHO-1PKC-εNrf2SH-SY5Y cellsSheep models of myocardial ischemiaStrokeNerve injuryAmyotrophic lateral sclerosisInhibitorinhibitorinhibit

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