1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. MIF-1

MIF-1  (Synonyms: Pro-Leu-Gly-NH2; Melanostatin)

目录号: HY-107663
产品使用指南

MIF-1 (Melanostatin) 是一种内源性的脑肽,是一种有效的多巴胺受体变构调节剂。MIF-1 抑制黑色素形成。MIF-1 阻断阿片受体激活的作用,从而调节吗啡的镇痛作用和应激诱导镇痛 (SIA)。MIF-1 直接通过血脑屏障 (BBB) 从血液进入中枢神经系统。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

MIF-1 Chemical Structure

MIF-1 Chemical Structure

CAS No. : 2002-44-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB)[1][2][3].

体外研究
(In Vitro)

MIF-1 (Melanostatin, 1 μM) provokes a reversible hyperpolarization and a suppression of spontaneous action potentials[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

MIF-1 (Melanostatin, 1 mg/kg; i.p.; once, for 1 hour; male Wistar rats) modulates the analgesic effects and stress-induced analgesia (SIA)[1].
MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; once, for 1 hour
Result: Decreased the analgesic effect. Increased the pain threshold for at least 1 h.
Animal Model: Sprague-Dawley rats[3]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; daily, for 8 weeks
Result: Attenuated the ontogenic impairment of striatal D2 receptors that was produced by spiroperidol (HY-B1371) treatment.
分子量

284.35

Formula

C13H24N4O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
MIF-1
目录号:
HY-107663
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