2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. MK 1256

MK 1256 是一种高选择性的、口服有效的组织蛋白酶 K (Cat K) 抑制剂，其 IC50 为 0.62 nM。MK 1256 对其它组织蛋白酶具有极高的选择性 (均 > 1100 倍)，仅对组织蛋白酶 F (Cat F) 的选择性稍低 (110 倍)。MK 1256 在卵巢切除 (OVX) 恒河猴骨质疏松模型中表现出强大的抗骨吸收活性。MK 1256 可用于研究骨质疏松。

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MK 1256

MK 1256 Chemical Structure

CAS No. : 919109-76-5

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MK 1256 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MK 1256 is a highly selective and orally active inhibitor of tissue protease K (Cat K) with an IC50 of 0.62 nM. MK 1256 shows extremely high selectivity towards other tissue proteases (all > 1100 times), with only a slightly lower selectivity for tissue protease F (Cat F) (110 times). MK 1256 exhibits strong anti-bone resorption activity in the osteoporosis model of rhesus monkeys with ovariectomy. MK 1256 can be used for research on osteoporosis[1].

分子量

563.42

Formula

C23H23Cl2F3N4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MK 1256 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK 1256919109-76-5MK1256MK-1256Cathepsincathepsin K inhibitorosteoporosisbone resorption shift(BRS)nitrilepharmacokineticsovariectomized(OVX) monkey modelInhibitorinhibitorinhibit

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HY-14360
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