2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. ML 10302 hydrochloride

ML 10302 hydrochloride 是一种高效、选择性的 5-HT4 受体 (5-HT4 receptor) 激动剂，其 EC50 值为 4 nM。ML 10302 hydrochloride 对 5-HT4 的选择性结合作用比 5-HT3 至少高出 680 倍。

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ML 10302 hydrochloride Chemical Structure

ML 10302 hydrochloride Chemical Structure

CAS No. : 186826-17-5

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规格 价格 是否有货
5 mg ￥1916
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Other Forms of ML 10302 hydrochloride:

ML 10302 hydrochloride 相关抗体

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查看 5-HT Receptor 亚型特异性产品:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].

IC50 & Target[1]

5-HT4 Receptor

4 nM (EC50)

5-HT4 Receptor

1.07 nM (Ki)

5-HT3 Receptor

782 nM (Ki)

体外研究
(In Vitro)

ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ML 10302 hydrochloride 相关抗体:
体内研究
(In Vivo)

ML 10302 hydrochloride (20 mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-weeks old adult male C57BL/6j wild-type mice (23-27 g)[3]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Subcutaneous injection
Result: Significantly increased sAPPα level in the cortex.
分子量

349.25

Formula

C15H22Cl2N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ML 10302 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML 10302186826-17-5ML10302ML-103025-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT4serotoninintestinalmotilitydisordersAlzheimer'sdiseasesolubleformofamyloidprecursorproteinsAPPαInhibitorinhibitorinhibit

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产品名称：
ML 10302 hydrochloride
目录号：
HY-14442
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