2. GPCR/G Protein
  3. Leukotriene Receptor
  4. Montelukast dicyclohexylamine

Montelukast dicyclohexylamine  (Synonyms: MK0476 dicyclohexylamine)

目录号: HY-13315B
产品使用指南

摩尔计算器

Montelukast (MK0476) dicyclohexylamine 是一种有效的、选择性和具有口服活性的半胱氨酸白三烯受体 1 (CysLT1) 拮抗剂。Montelukast dicyclohexylamine 可用于研究预防哮喘和肝损伤。Montelukast dicyclohexylamine 在肠缺血-再灌注损伤中也具有抗氧化作用，还可以减少心脏损伤。Montelukast dicyclohexylamine 减少嗜酸性粒细胞浸润到哮喘气道。Montelukast dicyclohexylamine 也可用于 COVID-19 的研究。

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Montelukast dicyclohexylamine Chemical Structure

Montelukast dicyclohexylamine Chemical Structure

CAS No. : 577953-88-9

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Montelukast dicyclohexylamine 的其他形式现货产品:

Customer Review

Other Forms of Montelukast dicyclohexylamine:

Montelukast dicyclohexylamine 相关抗体

Top Publications Citing Use of Products

查看 Leukotriene Receptor 亚型特异性产品:

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Montelukast (MK0476) dicyclohexylamine is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast dicyclohexylamine can be used for the reseach of asthma and liver injury. Montelukast dicyclohexylamine also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast dicyclohexylamine decreases eosinophil infiltration into the asthmatic airways. Montelukast dicyclohexylamine can also be used for COVID-19 research[1][2][3][4].

IC50 & Target

CysLT1

 

体外研究
(In Vitro)

Montelukast (5 μM; 1 h) inhibits APAP (Acetaminophen) (HY-66005)-induced cell damage[1].
Montelukast (0.01-10 μM; 30 min) diminishes the 5-oxo-ETE–induced cell migration and modulates the activation of the plasmin-plasminogen system[3].
Montelukast (10 μM; 18 h) modulates the activation of MMP-9[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Montelukast dicyclohexylamine 相关抗体:

Cell Migration Assay [3]

Cell Line: Eosinophils
Concentration: 0.01-10 μM
Incubation Time: 30 min
Result: Diminished the 5-oxo-ETE–induced cell migration.

Western Blot Analysis[3]

Cell Line: Eosinophils
Concentration: 10 μM
Incubation Time: 18 h
Result: Reduced the 5-oxo-ETE–boosted MMP-9 secretion.
体内研究
(In Vivo)

Montelukast (3 mg/kg; oral gavage) protects against APAP-induced hepatotoxicity in mice[1].
Montelukast (1 mg/kg; miniosmotic pump administration) reduces the airway remodeling changes observed in OVA-treated mice and blocks the actions of cysteinyl leukotrienes (LT) C4, D4, and E4 mediated by the CysLT1 receptor[2].
Montelukast (1 mg/kg; miniosmotic pump administration) reduces the elevated levels of IL-4 and IL-13 found in the BAL fluid of OVA-treated mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (8-week-old; 22-25 g) are induced acute hepatic injury[1]
Dosage: 3 mg/kg
Administration: Oral gavage 1 h after saline or APAP administration
Result: Decreased serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST), and alleviated liver damage.
Clinical Trial
分子量

767.50

Formula

C47H59ClN2O3S
CAS 号
性状

固体

颜色

White to off-white

中文名称

孟鲁司特二环己基胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Montelukast dicyclohexylamine 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Montelukast577953-88-9MK0476孟鲁司特二环己基胺MK 0476MK-0476Leukotriene ReceptorcysteinylleukotrieneCysltr1asthmaliverinjuryantioxidantintestinalischemia–reperfusionicardiacdamageCOVID-19Inhibitorinhibitorinhibit

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