2. Epigenetics PROTAC
  3. Histone Methyltransferase PROTACs
  4. MS33

MS33 是一种有效的 WDR5 降解剂，对 VCB 和 WDR5 的 Kd 值分别为 870 nM 和 120 nM。MS33 以 E3 连接酶 VHL 和蛋白酶体依赖性方式诱导 WDR5 降解。MS33 可用于急性髓系白血病的研究。

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MS33 Chemical Structure

MS33 Chemical Structure

CAS No. : 2407449-11-8

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MS33 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].

IC50 & Target[1]

VHL

 

WDR5

120 nM (Kd)

VCB

870 nM (Kd)

体外研究
(In Vitro)

MS33 (0.05-5 μM; 18 h) induces WDR5 degradation in a concentration-dependent manner in MV4;11 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MS33 相关抗体:

Western Blot Analysis[1]

Cell Line: MV4;11 cells
Concentration: 0.05, 0.1, 0.5, 1, 5 μM
Incubation Time: 1, 2, 4, 8, 16, 24 hours
Result: Concentration- and time-dependently induced WDR5 degradation.
The DC50 of MS33 was 260 nM, and the maximum degradation of 71%.
分子量

1208.48

Formula

C64H84F3N11O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MS33 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS332407449-11-8MS 33MS-33Histone MethyltransferasePROTACsWDR5VCBE3ligaseVHLproteasomeacutemyeloidleukemiaInhibitorinhibitorinhibit

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