2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. MSG606 TFA

MSG606 TFA 是一种选择性的黑皮质素 1 受体 (MC1R) 拮抗剂。MSG606 TFA 能够消除 BMS-470539 (HY-15616) (MC1R 激动剂) 的神经保护作用。MSG606 TFA 可以抑制癌细胞增殖以及从 G1 期到 S 期的转换。MSG606 TFA 能够延缓疼痛超敏反应并降低胆固醇水平。MSG606 TFA 可用于癌症、炎症、神经系统和代谢性疾病的研究，如乳腺癌和蛛网膜下腔出血 (SAH)。

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Custom Peptide Synthesis

MSG606 TFA

MSG606 TFA Chemical Structure

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MSG606 TFA 的其他形式现货产品:

Customer Review

Other Forms of MSG606 TFA:

MSG606 TFA 相关抗体

Top Publications Citing Use of Products

查看 Melanocortin Receptor 亚型特异性产品:

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MC1R MC3R MC2R MC4R MC5R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MSG606 TFA is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 TFA can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 TFA can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 TFA can delay pain hypersensitivity and reduce cholesterol levels. MSG606 TFA can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH)[1][2][3][4].

IC50 & Target

MC1R

 

体外研究
(In Vitro)

MSG606 TFA (20 μM, 3 h) 可减弱 NDP-MSH 刺激引起的 T-47d 和 MCF7 细胞中 cAMP 的增加[3]。
MSG606 TFA (20 μM, 6 h) 可抑制 NDP-MSH 刺激的 T-47d 和 MCF7 细胞的增殖[3]。
MSG606 TFA (20 μM, 0-12 h) 会延长 NDP-MSH 刺激的 T-47d 细胞从 G1 期向 S 期转换所需的时间[3]。
MSG606 TFA (5-20 μM, overnight) 可降低 NDP-MSH 刺激的 T-47d、MCF7 和 HEK 293 T 细胞中 CREB、ATF-1、ERK 磷酸化水平以及 p-65 NFκB 的水平[3]。
MSG606 TFA (1 μmol/L, 30 mins) 可减弱 oxLDL 诱导的 BMDMs 中 LXRα 表达的增加[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MSG606 TFA 相关抗体:

Western Blot Analysis[3]

Cell Line: T-47d, MCF7 and HEK 293 T cells
Concentration: 5, 10 and 20 μM
Incubation Time: Overnight
Result: Decreased CREB, ATF-1, the phosphorylation of ERK and p-65 NFκB levels
体内研究
(In Vivo)

MSG606 TFA (6 nM，颅内注射，SAH 前 1 小时) 可消除 BMS-470539 (HY-15616) 对蛛网膜下腔出血 (SAH) 大鼠的抗炎作用[1]。
MSG606 TFA (7.5 μg，颅内注射) 延长了吗啡处理的雌性小鼠的痛觉过敏潜伏期[2]。
MSG606 TFA (1 mg/kg，腹腔注射，每日一次，持续 4 周) 可降低富含胆固醇的高脂饮食小鼠的总胆固醇水平，并增加斑块稳定性标志物[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Subarachnoid hemorrhage (SAH) rats models[1]
Dosage: 6 nM
Administration: Intracerebrally injection, 1 h befor SAH
Result: Increased levels of NFκB, IL-1β, and TNFα.
Reduced p-AMPK and p-TBK1.
Animal Model: Mice with cholesterol-rich high-fat diet[4]
Dosage: 1 mg/kg
Administration: Intraperitoneally injection, daily for 4 weeks
Result: Reduced total cholesterol levels.
Increases markers of plaque stability.
increased hepatic ABCA1 and ABCG1 and LDL receptor mRNA levels.
Reduced monocyte counts in the aorta and modulates circulating monocyte profile.
分子量

1347.51 (free base)

Formula

C62H82N20O13S.xC2HF3O2
性状

固体

颜色

White to off-white

Sequence Shortening

{Bua}GH-{d-Phe}-R-{d-Trp}-CDRFG-NH2 (Carba sulfide bridge:Bua1-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MSG606 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MSG606MSG 606MSG-606Melanocortin ReceptorMC ReceptorMC1RBMS-470539T-47d and MCF7SAHBreast cancerInhibitorinhibitorinhibit

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目录号：
HY-P1726A
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