2. Membrane Transporter/Ion Channel
  3. Sodium Channel Potassium Channel
  4. Nav1.8-IN-7

Nav1.8-IN-7 (Example 116) 是选择性 Nav1.8 抑制剂。Nav1.8-IN-7 显示在浓度为 100 nM 时对 Nav1.8 的抑制率为大于 50%。Nav1.8-IN-7 抑制 hERG，IC50 为 15.6 μM。Nav1.8-IN-7 具有用于疼痛研究潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Nav1.8-IN-7 Chemical Structure

Nav1.8-IN-7 Chemical Structure

CAS No. : 2761181-58-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Nav1.8-IN-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research[1].

体外研究
(In Vitro)

Nav1.8-IN-9 (Example 116；1 μM) 显示对 Nav1.1、Nav1.3、Nav1.4、Nav1.5、Nav1.6 和 Nav1.7 的抑制率分别为 1.2％、3.7％、<1％、<1％、2.6％、<1％[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nav1.8-IN-7 相关抗体:
体内研究
(In Vivo)

Pharmacokinetic Parameters of Nav1.8-IN-7 in male Sprague-Dawley rats[1].

PO (100 mg/kg)
Cmax (ng/mL) 2566
AUC0-24 (ng/mL∗h) 42454
t1/2 (h) 8.7

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

515.84

Formula

C22H18ClF4N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    5％ DMSO + 95％ saline 对受试化合物进行混悬，并经涡旋 2 min，超声 5min 之后配制成给药体系。

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Nav1.8-IN-7 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nav1.8-IN-72761181-58-0Sodium ChannelPotassium ChannelNa channelsNa+ channelsKcsAOrallyNav1.8painInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Nav1.8-IN-7
目录号：
HY-160588
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z