2. Metabolic Enzyme/Protease Apoptosis
  3. Cathepsin Apoptosis
  4. NCO-700

NCO-700 是一种双重组织蛋白酶 B (cathepsin B) 和钙激活中性蛋白酶 (CANP) 抑制剂，其 IC50 为 0.8 和 46 μM。NCO-700 通过抑制蛋白酶活性，减少心肌纤维蛋白的降解。NCO-700 对激素非依赖性肿瘤细胞，如前列腺癌细胞具有抑制作用，且诱导细胞凋亡 (apoptosis)。NCO-700 可用于研究心肌缺血和难治性激素非依赖性肿瘤。

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NCO-700

NCO-700 Chemical Structure

CAS No. : 84518-80-9

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NCO-700 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NCO-700 is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC50 values of 0.8 and 46 μM, respectively. NCO-700 reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 can be used to study myocardial ischemia and refractory hormone-independent tumors[1][2].

体外研究
(In Vitro)

NCO-700 (7 days) 抑制 HS-578T、PC-3、DU-145、MCF-7、LNCaP 和 T47D 细胞增殖，IC50 分别为 7.5、10、11.5、72 和 > 100 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NCO-700 相关抗体:
体内研究
(In Vivo)

NCO-700 (总剂量：20-40 mg/kg，腹腔注射，分次给药共 4 次) 可减少兔和犬心肌梗死模型中的梗死面积[1]。
NCO-700 (10-100 mg/kg，腹腔注射，每日一次，连续 5 天) 在小鼠前列腺癌和乳腺癌异种移植模型中显示出显著的抗肿瘤活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Myocardial infarction model established in male albino rabbit and mongrel dog[1][3]
Dosage: 20 and 40 mg/kg (total dose)
Administration: Intraperitoneal injection (i.p.), 4 administrations of medication
Result: Reduce the infarcted area by 11.5% and 22.3% at 20 and 40 mg/kg in rabbit model.
Significantly inhibited the degradation of myofibrillar proteins induced by ischemia in dog model.
Animal Model: Xenograft models of prostate cancer and breast cancer established in Balb/C mice[2]
Dosage: 10, 20 and 40 mg/kg (prostate cancer) and 10, 50 and 100 mg/kg (breast cancer)
Administration: Intraperitoneal injection (i.p.), once daily for 5 days
Result: Significantly slowed down the growth rate of the tumor.
Induced cell apoptosis in cancer cells removed from animals.
分子量

521.60

Formula

C26H39N3O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NCO-700 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

NCO-70084518-80-9NCO700NCO 700CathepsinApoptosisCalcium-activatedneutral proteaseProtease inhibitorAcute myocardial infarctionContractilityInhibitorinhibitorinhibit

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HY-106058
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