Nialamide hydrochloride 

Nialamide hydrochloride is a non-selective monoamine oxidase (MAO) inhibitor. Nialamide hydrochloride inhibits MAO and regulates ROS production. Nialamide hydrochloride induces hyperkinesis in animals, enhances the anticonvulsant effect of Diphenylhydantoin in mice, increases rectal temperature, and enhances the pressor effect of Norepinephrine. Nialamide hydrochloride can be used in the research of depression, inflammatory diseases, neurodegenerative diseases, and hypertension^{[1][2][3][4][5][6]}.

Nialamide (10 μM) hydrochloride 可降低 NMDA (HY-17551) 和 Kainic acid (HY-N2309) 刺激的大鼠小脑颗粒细胞中的 ROS 水平^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nialamide (100 mg/kg；皮下注射) hydrochloride 可增强雌性 NMRI 小鼠的运动亢进^[3]。
Nialamide (1-10 mg/kg；静脉注射) hydrochloride 可增强去甲肾上腺素在经 Reserpine (HY-N0480) 预处理的髓质猫中的升压作用^[4]。
Nialamide (100 mg/kg；腹腔注射) hydrochloride 可增强 Diphenylhydantoin 在小鼠体内的抗惊厥作用^[5]。
Nialamide (200 mg/kg；腹腔注射) hydrochloride 可诱导小鼠运动活动增加、直肠温度升高，并升高脑内 5-HT、NA 和多巴胺水平^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

334.80

C₁₆H₁₉ClN₄O₂

1161-03-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Boldyrev AA, et al. Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells. Biochem Biophys Res Commun. 1999 Mar 16;256(2):320-4.  [Content Brief]

  [2]. Lee H, et al. Ionizing radiation induced modification of nialamide as an anti inflammatory agent against lipopolysaccharide induced RAW 264.7 and DH82 cells. Exp Ther Med. 2024 Mar 11;27(5):192.  [Content Brief]

  [3]. Buus Lassen J. Nialamide-induced hypermotility in mice treated with inhibitors of monoamine uptake, 5-HT antagonists and lithium. Psychopharmacology (Berl). 1989;98(2):257-61.  [Content Brief]

  [4]. DAVEY MJ, et al. The effects of nialamide on adrenergic functions. Br J Pharmacol Chemother. 1963 Feb;20(1):121-34.  [Content Brief]

  [5]. P'AN SY, et al. Anticonvulsant effect of nialamide and diphenylhydantoin. Proc Soc Exp Biol Med. 1961 Dec;108:680-3.  [Content Brief]

  [6]. Modigh K, et al. On the role of central nervous system catecholamines and 5-hydroxytryptamine in the nialamide-induced behavioural syndrome. Br J Pharmacol. 1972 Sep;46(1):32-45.  [Content Brief]