2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Nimotuzumab (powder)

Nimotuzumab (powder) 是一种靶向 EGFR 的人源化 IgG1 单克隆抗体，KD 值为 0.21 nM。Nimotuzumab (powder) 针对 EGFR 的细胞外结构域，阻断与其配体的结合。Nimotuzumab (powder) 是一种强抗肿瘤活性分子，通过其引起抗体依赖性细胞介导的细胞毒性 (ADCC) 和补体依赖性细胞毒性(CDC) 的能力，对靶肿瘤具有溶细胞作用。

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Nimotuzumab (powder)

Nimotuzumab (powder) Chemical Structure

CAS No. : 780758-10-3

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Nimotuzumab (powder) 相关抗体

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nimotuzumab (powder) is a humanized IgG1 monoclonal antibody targeting EGFR with a KD value of 0.21 nM. Nimotuzumab (powder) is directed against the extracellular domain of the EGFR blocking the binding to its ligands. Nimotuzumab (powder), a strong antitumor agent, is cytolytic on target tumors by its capacity to cause antibody dependent cell mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC)[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
基因 ID

1956  [NCBI]

Accession
靶点

ERBB1/EGFR/HER1
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

147.58 kDa

CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nimotuzumab (powder) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nimotuzumab (powder)780758-10-3EGFREpidermal growth factor receptorErbB-1HER1IgG1antibodyADCCCDCInhibitorinhibitorinhibit

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