2. Cell Cycle/DNA Damage
  3. Topoisomerase DNA/RNA Synthesis
  4. NK-611

NK-611 是一种表鬼臼毒素衍生物。NK-611 通过抑制拓扑异构酶 II (topoisomerase II) (IC50 = 56 μM) 诱导 DNA 双链断裂。NK-611 不抑制微管聚合，避免了母体化合物 Podofilox (HY-15552) 的副作用。NK-611 具有广谱抗肿瘤活性，并且在白血病体内模型中展现出强大的疗效。NK-611 可用于癌症研究。

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NK-611

NK-611 Chemical Structure

CAS No. : 105655-99-0

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NK-611 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NK-611 is an epipodophyllotoxin derivative. NK-611 induces DNA double-strand breaks by inhibiting topoisomerase II (IC50 = 56 μM). NK-611 does not inhibit microtubule polymerization, thus avoiding the side effects of the parent compound, Podofilox (HY-15552). NK-611 exhibits broad-spectrum antitumor activity and demonstrates potent efficacy in in vivo models of leukemia. NK-611 can be used in cancer research[1][2].

IC50 & Target[1]

Topoisomerase II

56 μM (IC50)

体外研究
(In Vitro)

NK-611 (0.51-51 μM, 1 h- 28 d) 对 L1210 细胞表现出强效的细胞毒性，IC50 为 0.33 μM，并且对包括肾细胞癌和结直肠癌在内的 17 种不同类型的肿瘤表现出时间依赖性的广谱抗肿瘤活性[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NK-611 相关抗体:
体内研究
(In Vivo)

NK-611 (腹腔注射，单剂量) 在小鼠白血病模型中表现出显著的抗肿瘤活性，其 ED50 为 0.9 mg/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

615.62

Formula

C31H37NO12
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NK-611 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NK-611105655-99-0VP 19NK611NK 611VP19VP-19TopoisomeraseDNA/RNA Synthesisepipodophyllotoxinderivativesetoposideactivityin vitroInhibitorinhibitorinhibit

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目录号：
HY-106122
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