1. Metabolic Enzyme/Protease Apoptosis
  2. Glutaminase Apoptosis
  3. NTU281

NTU281 是一种有效的转谷氨酰胺酶-2 (transglutaminase-2) 抑制剂。NTU281 能降低糖尿病大鼠血清肌酐和蛋白尿的升高。NTU281 还能降低肾小球 I 型胶原积累、Hic-5 和α-SMA 表达,以及减少细胞凋亡 (apoptosis)。NTU281 可用于研究糖尿病引起的肾小球硬化。

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NTU281 Chemical Structure

NTU281 Chemical Structure

CAS No. : 815619-12-6

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生物活性

NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes[1][2].

体内研究
(In Vivo)

NTU281 (2.5 μl/h of 50 mM; cannulate to deliver into kidneys) reduces glomerular collagen I overexpression as well as the increases in glomerular Hic-5 and α-SMA expression; also decreases serum creatinine, albuminuria, glomerulosclerosis and tubulointerstitial scarring in diabetic rats[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar Han rats [subjected to right uninephrectomy, then induced hyperglycemia by tail vein injection of streptozotocin (35 mg/kg in citrate buffer pH 4)][1]
Dosage: 2.5 μl/h of 50 mM
Administration: Cannulated to deliver into kidneys
Result: Reduced glomerular collagen I overexpression by ~50%; reduced the increases in glomerular Hic-5 expression; reduced diabetic nephropathy-induced α-SMA expression.
Animal Model: Male Wistar Han rats [subjected to right uninephrectomy, then induced hyperglycemia by tail vein injection of streptozotocin (35 mg/kg in citrate buffer pH 4)][2]
Dosage: Various concentration
Administration: Cannulated to deliver into kidneys
Result: Significantly reduced the increases in serum creatinine (-68%) and albuminuria (-80%) in diabetic rats during eight-month experimental period; reduced in glomerulosclerosis (-76.6%) and tubulointerstitial scarring (-68.2%) as a result of lowered accumulation of collagen I, III and IV; and reduced numbers of myofibroblasts present.
分子量

487.59

Formula

C25H31N2O6S+

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NTU281
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HY-100446
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