1. 寡核苷酸
  2. CpG寡核苷酸
  3. ODN MT01

ODN MT01 是根据人类线粒体 DNA 序列设计的,是一种具有促进骨细胞分化的抑制性寡核苷酸。ODN MT01 可促进大鼠成骨细胞成熟和活化,减少牙周炎导致的大鼠牙槽骨吸收,调节成骨相关因子的表达水平。

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DNA, d(A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T)

ODN MT01 Chemical Structure

CAS No. : 1817821-77-4

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

体外研究
(In Vitro)

ODN MT01 可促进BMSCs增殖、向成骨细胞分化,并促进Runx2、Osterix、OPG、RANKL和collagen I的mRNA表达。[2]

ODN MT01 影响 MG63 细胞的细胞周期,促进细胞增殖[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

ODN MT01 抑制牙周炎大鼠牙槽骨丢失,诱导骨组织OPG和Osterix蛋白产生[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS 号
Sequence

DNA, d(A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ODN MT01
目录号:
HY-150214
需求量: