1. Apoptosis
  2. Apoptosis
  3. Omigapil maleate

Omigapil maleate (Synonyms: CGP3466B maleate)

目录号: HY-16361A
产品使用指南

Omigapil maleate (CGP3446B maleate) 是一种有效的,具有口服活性的凋亡 (apoptosis) 抑制剂。Omigapil maleate 可用于研究先天性肌营养不良 (CMD)。Omigapil maleate 是一种 GAPDH 亚硝基化抑制剂,可消除 Aβ1-42 诱导的小鼠 tau 乙酰化,记忆障碍和运动功能障碍,Omigapil maleate 具有研究阿尔茨海默症的潜力。

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Omigapil maleate Chemical Structure

Omigapil maleate Chemical Structure

CAS No. : 200189-97-5

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Description

Omigapil maleate (CGP3446B maleate) is an orally bioavailable apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD)[1]. Omigapil maleate, a GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice, suggesting that Omigapil maleate has the potential for the research of Alzheimer's disease[2].

IC50 & Target

Apoptosis[2]

In Vivo

Treatment of mice with Omigapil (0.1 mg/kg) results in improved muscle regeneration and increased force[1].

Animal Model: 12-week-old dyW/ mag mice[1]
Dosage: 0.1 mg/kg
Administration: For the first week of drug treatment, administered once daily by intraperitoneal injection.
After weaning (3 weeks of age), applied once daily by oral gavage.
Result: Reduced the muscle fibre loss.
Many of the functional parameters were significantly improved by omigapil.
Molecular Weight

391.42

Formula

C₂₃H₂₁NO₅

CAS No.

200189-97-5

中文名称

奥米加匹马来酸盐

SMILES

C#CCN(C)CC1=CC2=CC=CC=C2OC3=CC=CC=C13.O=C(O)/C=C\C(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

OmigapilCGP3466BApoptosisanti-apoptosiscongenitalmusculardystrophyCMDGAPDHnitrosylationtauacetylationmemoryimpairmentlocomotordysfunctionAlzheimerdiseaseInhibitorinhibitorinhibit

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产品名称:
Omigapil maleate
目录号:
HY-16361A
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