2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Ondelopran

Ondelopran (LY 2196044) 是一种非选择性阿片受体 (opioid receptor) 拮抗剂。Ondelopran 拮抗 μ、κ、δ 阿片受体 (μ/κ/δ opioid receptor)，尤其对 μ 受体有较高亲和力。Ondelopran 抑制酒精诱导的伏隔核多巴胺释放，削弱饮酒的奖赏效应，降低渴求感。Ondelopran 可用于酒精使用障碍 (AUD)。

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Ondelopran

Ondelopran Chemical Structure

CAS No. : 676501-25-0

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Ondelopran 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ondelopran (LY 2196044) is a non-selective opioid receptor antagonist. Ondelopran blocks the μ/κ/δ opioid receptor, with a particularly high affinity for the μ receptor. Ondelopran inhibits the release of dopamine in the nucleus accumbens induced by alcohol, reduces the rewarding effect of alcohol consumption, and lowers the craving. Ondelopran can be used for alcohol use disorder (AUD)[1].

IC50 & Target[1]

μ Opioid Receptor/MOR

 

κ Opioid Receptor/KOR

 

δ Opioid Receptor/DOR

 

分子量

373.42

Formula

C20H24FN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ondelopran 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ondelopran676501-25-0LY 2196044LY2196044LY-2196044Opioid Receptoropioid receptor antagonistalcohol use disorderheavy drinking dayspharmacogeneticsDRD4 VNTR polymorphismclinical trialalcohol consumption reductionInhibitorinhibitorinhibit

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目录号：
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