2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. Peonidin 3-O-glucoside chloride

Peonidin 3-O-glucoside chloride 

目录号: HY-W040127 纯度: 98.02%
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Peonidin 3-O-glucoside chloride 是游离脂肪酸受体 FFAR1 和葡萄糖激酶 (Glucokinase) 的激动剂。Peonidin 3-O-glucoside chloride 能够增强胰腺 β 细胞的胰岛素分泌，增加肝细胞对葡萄糖的摄取。Peonidin 3-O-glucoside chloride 激活 FFAR1，促进胰岛素分泌途径中相关蛋白的磷酸化，以及增加 FFAR1 的表达。在肝细胞中，Peonidin 3-O-glucoside chloride 激活 GK 并调节与碳水化合物代谢相关的蛋白质。Peonidin 3-O-glucoside chloride 可用于糖尿病研究。

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Peonidin 3-O-glucoside chloride

Peonidin 3-O-glucoside chloride Chemical Structure

CAS No. : 6906-39-4

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1 mg ￥1180
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5 mg ￥3600
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Peonidin 3-O-glucoside chloride 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Peonidin 3-O-glucoside chloride is an agonist of the free fatty acid receptor FFAR1 and Glucokinase. Peonidin 3-O-glucoside chloride enhances insulin secretion of pancreatic beta cells and increases glucose uptake by liver cells. Peonidin 3-O-glucoside chloride activates FFAR1, promotes the phosphorylation of related proteins in the insulin secretion pathway, and increases the expression of FFAR1. In liver cells, Peonidin 3-O-glucoside chloride activates GK and regulates proteins associated with carbohydrate metabolism. Peonidin 3-O-glucoside chloride can be used in diabetes research[1][2].

体外研究
(In Vitro)

Peonidin 3-O-glucoside (1-100 μM；24 h) 提高 INS-1E 胰腺 β 细胞受葡萄糖刺激而分泌的胰岛素水平，增加 FFAR1 依赖的胰岛素分泌途径相关蛋白的表达，如 FFAR1、PLC 和 PKD 的磷酸化[1]。
Peonidin 3-O-glucoside (100 μM；24 h) 增加 HepG2 肝细胞中葡萄糖摄取，激活葡萄糖激酶 (GK)，并调节与碳水化合物代谢相关的蛋白质，例如增加 AMP 激活的蛋白激酶 (AMPK) 的磷酸化水平，降低磷酸烯醇式丙酮酸羧激酶 (PEPCK) 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Peonidin 3-O-glucoside chloride 相关抗体:

Cell Viability Assay[1]

Cell Line: INS-1E pancreatic β-cells
Concentration: 1-100 μM
Incubation Time: 24 h
Result: The cells were treated with peonidin 3-O-glucoside at concentrations ranging from 1 to 100 μM for 24 h.
The results showed that compared with the untreated control group, the glucose-stimulated insulin secretion (GSIS) was enhanced by 18%-40%.
Western blot analysis indicated that the expression of proteins related to the FFAR1-dependent insulin secretory pathway, including FFAR1, PLC, and the phosphorylation of PKD, was increased.

Western Blot Analysis[1]

Cell Line: HepG2 hepatic cells
Concentration: 100 μM
Incubation Time: 24 h
Result: After treating HepG2 cells with 100 μM peonidin 3-O-glucoside for 24 h, the glucose uptake in these cells was increased by 19% compared to the untreated group.
Western blot analysis revealed that the phosphorylation of AMP-activated protein kinase (AMPK) was increased, and the expression of phosphoenolpyruvate carboxykinase (PEPCK) was reduced.
The activity of glucokinase (GK) was also activated, which indicated that peonidin 3-O-glucoside could modulate the carbohydrate metabolism in HepG2 cells.
分子量

498.86

Formula

C22H23ClO11
CAS 号
性状

固体

颜色

Brown to black

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 5 mg/mL (10.02 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0046 mL 10.0229 mL 20.0457 mL
5 mM 0.4009 mL 2.0046 mL 4.0091 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Peonidin 3-O-glucoside chloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0046 mL 10.0229 mL 20.0457 mL 50.1143 mL
5 mM 0.4009 mL 2.0046 mL 4.0091 mL 10.0229 mL
10 mM 0.2005 mL 1.0023 mL 2.0046 mL 5.0114 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peonidin 3-O-glucoside6906-39-4Insulin Receptoranthocyanininsulin secretagogueglucoseuptakeHepG2type-2 diabetesInhibitorinhibitorinhibit

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