2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. PI3K/mTOR Inhibitor-13

PI3K/mTOR Inhibitor-13 是一种具有口服活性的磷酸肌醇 3-激酶 (PI3K) 和 mTOR 激酶双重抑制剂。PI3K/mTOR Inhibitor-13 在性疾病、实体瘤和特发性肺纤维化 (IPF) 中有潜在应用。

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PI3K/mTOR Inhibitor-13 Chemical Structure

PI3K/mTOR Inhibitor-13 Chemical Structure

CAS No. : 1621718-37-3

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PI3K/mTOR Inhibitor-13 的其他形式现货产品:

Customer Review

Other Forms of PI3K/mTOR Inhibitor-13:

PI3K/mTOR Inhibitor-13 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K/mTOR Inhibitor-13 is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF)[1][2].

体外研究
(In Vitro)

PI3K/mTOR Inhibitor-13 (Compound A) (0-2 µM；48 h) 以剂量依赖性方式抑制 HFL1 细胞的增值[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PI3K/mTOR Inhibitor-13 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HFL1 cells.
Concentration: 0, 0.03125, 0.0125, 0.025, 0.05, 0.0625, 0.1, 0.125, 0.2, 0.25, 0.4, 0.5, 1 and 2 µM.
Incubation Time: 48 h.
Result: Showed inhibitory for HFL1 cells.

Western Blot Analysis[1]

Cell Line: HFL1 cells.
Concentration: 200 nM.
Incubation Time: 48 h.
Result: Increased the expression of α-SMA/Tubulin.
体内研究
(In Vivo)

PI3K/mTOR Inhibitor-13 的药代动力学 (PK) 参数[2]

Species Administration manner Dose (mg/kg) T1/2 (h) AUClast (ng•h/mL) Cl/F (L/h/kg) Vss (L/kg) F (%)
Rat Intravenous injection 2 2.77 7069 0.29 0.85 94.75
Mice Intravenous injection 1 5.45 57059 0.02 0.13 79.3
Dog Intravenous injection 1 0.67 3672 0.27 0.23 108.5
Monkey Intravenous injection 1 9.70 5978 0.16 0.92 59.8

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

441.41

Formula

C20H13F2N5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PI3K/mTOR Inhibitor-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3K/mTOR Inhibitor-131621718-37-3PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycinHFL1 cellsRatMiceDogMonkeyInhibitorinhibitorinhibit

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HY-153120
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