1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
  3. PM226

PM226 

目录号: HY-136238
产品使用指南

PM226 是一种选择性的大麻素 CB2R 激动剂 (Ki (CB2R)=13 nM;EC50 (CB2R)=39 nM;Ki (CB1R) >40 μM),在体内外均具有神经保护特性。

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PM226 Chemical Structure

PM226 Chemical Structure

CAS No. : 1949726-13-9

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Description

PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo[1].

IC50 & Target[1]

CB2

13 nM (Ki)

CB2

39 nM (EC50)

In Vitro

PM226 binds selectively to CB2 receptor with an affinity in the nanomolar range (Ki=12.8±2.4 nM). PM226 has negligible affinity for the CB1 receptor (Ki >40000 nM) and no activity at the GPR55. PM226 was also evaluated in GTPγS binding assays specific to the CB2 receptor showing agonist activity (EC50=38.67±6.70 nM)[2].

In Vivo

PM226 (0.1, 1 and 10 mg/kg; administered i.p.) administration decreases the volume of the striatal lesion caused by Malonate[2].

Animal Model: Malonate-lesioned adult (12 week old; 350-400 g) male Wistar rats[2]
Dosage: 0.1, 1 and 10 mg/kg
Administration: Administered i.p.
Result: Reduced the volume of edema observed in Malonate-lesioned rats at the dose of 1 mg/kg.
Molecular Weight

357.49

Formula

C₂₂H₃₁NO₃

CAS No.

1949726-13-9

SMILES

CC1(C)OC2=CC(C(C)(C)CCCCCC)=CC(OC)=C2C3=C1C=NO3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PM226PM 226PM-226Cannabinoid ReceptorcannabinoidCB2RneuroprotectiveInhibitorinhibitorinhibit

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产品名称:
PM226
目录号:
HY-136238
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