2. Apoptosis MAPK/ERK Pathway GPCR/G Protein
  3. c-Myc Ras Apoptosis
  4. PQ32

PQ32 是一种靶向 c-MYC Pu27 和 KRAS G-四链体的抗肿瘤剂。PQ32 抑制肿瘤细胞增殖，将肿瘤细胞周期阻滞于 G2 期，并诱导其凋亡 (apoptosis)。PQ32 抑制 c-MYC 和 KRAS 基因的表达。PQ32 能够抑制小鼠体内的肿瘤生长，可用于淋巴瘤、乳腺癌、肺癌、肝细胞癌、结直肠癌等癌症的研究。

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PQ32

PQ32 Chemical Structure

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PQ32 相关抗体

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PQ32 is an antitumor agent that targets c-MYC Pu27 and KRAS G-quadruplexes. PQ32 inhibits tumor cell proliferation, arrests the cell cycle at the G2 phase, and induces apoptosis. PQ32 inhibits the expression of c-MYC and KRAS genes. PQ32 can inhibit tumor growth in mice and is used in the study of lymphoma, breast cancer, lung cancer, hepatocellular carcinoma, colorectal cancer, and other cancers[1].

IC50 & Target[1]

K-RAS

 

体外研究
(In Vitro)

PQ32 对 RAJI、CA46、MDA-MB-231、A549、HepG2、HT29 和 HEK-293T 细胞均表现出抗肿瘤活性，IC50 分别为 1.75、2.68、1.07、3.48、2.72、1.50 和 4.09 μM[1]。
PQ32 (1.5 μM，24 小时) 可诱导 MDA-MB-231 细胞周期停滞和凋亡[1]。
PQ32 (1.5-3 μM，24-72 小时) 可抑制 MDA-MB-231 细胞中 c-MYC 和 KRAS 基因及蛋白的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PQ32 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231
Concentration: 1.5 μM
Incubation Time: 24 h
Result: Arrested the cells in the G2 phase (increasing from 4.01% to 27.01%).

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 1.5 μM
Incubation Time: 24 h
Result: Induced cell apoptosis(46.84%)

RT-PCR[1]

Cell Line: MDA-MB-231
Concentration: 1.5 μM, 3 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Inhibited c-MYC and KRAS gene expression.

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 1.5 μM, 3 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Inhibited c-MYC and KRAS protein expression.
体内研究
(In Vivo)

PQ32 (15 mg/kg，瘤内注射，两天一次，21 天) 抑制 HT29 异种移植裸鼠体内的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HT29 cancer xenografts (5 × 106 cells, s.c.) female nude mice (BALB/c, 4-weeks old, 14-17 g) [1]
Dosage: 15 mg/kg
Administration: intratumoral injection, every other day, 21 days
Result: Resulted in a significant reduction in tumor weight with tumor growth inhibition of 59%, displayed time-dependent inhibition of tumor growth.
分子量

483.47

Formula

C27H21N3O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PQ32 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PQ32PQ 32PQ-32c-MycRasApoptosisMycAntitumor AgentMDA-MB-231 cellsHT29 cellsNude miceInhibitorinhibitorinhibit

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