2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. ProTx-III

ProTx-III  (Synonyms: μ-TRTX-Tp1a)

目录号: HY-P5153
产品使用指南

摩尔计算器

ProTx-III 是选择性，有效的电压门控钠离子通道 Nav1.7 抑制剂， IC50 值为 2.1 nM。ProTx-III 是一种从秘鲁绿绒狼蛛的毒液中分离得到的蜘蛛毒液肽。ProTx-III 具有一个典型的抑制剂胱氨酸结基序 (ICK)。ProTx-III 能够逆转疼痛反应。ProTx-III 可用于慢性疼痛、癫痫和心律失常等疾病的研究。

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Custom Peptide Synthesis

ProTx-III Chemical Structure

ProTx-III Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

ProTx-III 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia[1].

IC50 & Target

Nav1.7

2.1 nM (IC50)

体外研究
(In Vitro)

原生，重组和合成的 C-末端酸和酰胺形式的 ProTx-III抑制 hNaV1.7 的 IC50 值分别为 2.1， 9.5， 11.5 和 2.5 nM[1]。
ProTx-III 抑制 hNav1.7，而不显著改变激活或失活的电压依赖性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ProTx-III 相关抗体:
体内研究
(In Vivo)

ProTx-III (0.01-1 μM; 足底注射) 在小鼠模型中可逆转通过足底内注射 OD1 诱导的小鼠自发性疼痛，从而证明其具有镇痛作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OD1-induced mouse model of pain(300Nm; intraplantar injection)[1]
Dosage: 100 nM, 300 nM, 1μM
Administration: intraplantar injection
Result: Showed at 1 μM (40 pmoles in a 40 μl injection) and 300 nM (12 pmoles in a 40 μl injection) significantly reduced spontaneous pain behaviour in a concentration dependent manner and this reduction in pain behaviour persisted for 25 min after injection of the highest concentration.
分子量

3802.40

Formula

C162H246N52O43S6
Sequence

Asp-Cys-Leu-Lys-Phe-Gly-Trp-Lys-Cys-Asn-Pro-Arg-Asn-Asp-Lys-Cys-Cys-Ser-Gly-Leu-Lys-Cys-Gly-Ser-Asn-His-Asn-Trp-Cys-Lys-Leu-His-Ile-NH2 (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
Sequence Shortening

DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ProTx-III 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ProTx-IIIμ-TRTX-Tp1aSodium ChannelNa channelsNa+ channelschronic painTp1aepilepsyarrhythmiapeptide toxinsInhibitorinhibitorinhibit

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