Pseudomonas quinolone signal  (Synonyms: PQS)

Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation^[1][2][3][4].

Pseudomonas quinolone signal (0-200 μM; 18 h) 在 P. aeruginosa strain PAO-R1 (lasR⁻) (pTS400) 中可诱导 lasB-lacZ 融合基因表达，并激活 β-半乳糖苷酶活性^[1]。
Pseudomonas quinolone signal (40 μM; 5-24 h) 在 P. aeruginosa PAO1 中可促进焦螯素、绿脓菌素合成，增加细菌对 H₂O₂ 的敏感性，并降低培养基中铁浓度^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

259.35

C₁₆H₂₁NO₂

108985-27-9

固体

White to light brown

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. Pesci E C, et al. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa[J]. Proceedings of the National Academy of Sciences, 1999, 96(20): 11229-11234.  [Content Brief]

  [2]. Bredenbruch F, et al. The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity. Environ Microbiol. 2006 Aug;8(8):1318-29.  [Content Brief]

  [3]. Cooke AC, et al. Pseudomonas Quinolone Signal-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa. mSphere. 2020 Nov 25;5(6):e01109-20.  [Content Brief]

  [4]. Lin J, et al. The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore. Front Cell Infect Microbiol. 2018 Jul 4;8:230.  [Content Brief]