2. GPCR/G Protein
  3. LPL Receptor
  4. (R)-FTY 720P

(R)-FTY 720P 是 FTY 720P 的 R 异构体。(R)-FTY 720P 对 S1P1,3,4,5 的结合亲和力比 (S)-异构体 (HY-15382) 弱。

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(R)-FTY 720P

(R)-FTY 720P Chemical Structure

CAS No. : 402616-23-3

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规格 价格 是否有货 数量
1 mg ￥2880
3 - 4 周
5 mg 询价 3 - 4 周
10 mg   询价  
50 mg   询价  

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(R)-FTY 720P 相关抗体

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P1,3,4,5 than (S)-Isomer (HY-15382)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
0.14 nM
Compound: FTY720-P
Agonist activity at human S1P1 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
Agonist activity at human S1P1 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
[PMID: 20153186]
CHO EC50
0.46 nM
Compound: FTY720-P
Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
[PMID: 20153186]
CHO EC50
0.68 nM
Compound: 2
Activity at human recombinant S1P1 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
Activity at human recombinant S1P1 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
[PMID: 17070046]
CHO EC50
0.7 nM
Compound: FTY720-P
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
[PMID: 20153186]
CHO EC50
1.7 nM
Compound: 2
Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
[PMID: 17070046]
CHO EC50
18.6 nM
Compound: 2
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
[PMID: 17070046]
CHO EC50
2.5 nM
Compound: FTY720-P
Agonist activity at human S1P3 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
Agonist activity at human S1P3 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
[PMID: 20153186]
CHO EC50
2.9 nM
Compound: 2
Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay
[PMID: 17070046]
CHO EC50
21.8 nM
Compound: (R)-5
Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO EC50
28.9 nM
Compound: (R)-5
Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO EC50
80.1 nM
Compound: (R)-5
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO EC50
> 10000 nM
Compound: (R)-5
Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO EC50
> 10000 nM
Compound: (R)-5
Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
[PMID: 16078855]
CHO IC50
0.16 nM
Compound: FTY720-P
Displacement of [33P]-S1P1 from human S1P1 receptor expressed in CHO cells
Displacement of [33P]-S1P1 from human S1P1 receptor expressed in CHO cells
[PMID: 20153186]
CHO IC50
> 22000 nM
Compound: FTY720-P
Agonist activity at human S1P2 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
Agonist activity at human S1P2 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
[PMID: 20153186]
体内研究
(In Vivo)

(R)-FTY 720P (静脉推注给药) 对麻醉大鼠的心率在剂量达到 0.3mg/kg 时没有明显影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

387.45

Formula

C19H34NO5P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(R)-FTY 720P 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-FTY 720P402616-23-3LPL ReceptorLysophospholipid ReceptorR-isomerFTY 720PInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-114061
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