Rhein-8-glucoside calcium  (Synonyms: 大黄酸-8-O-β-D-葡萄糖苷)

Rhein-8-glucoside calcium, an anthraquinone compound, is isolated from the EtOH extract of the roots of Saussurea lappa. Rhein-8-glucoside calcium is an hPTP1B inhibitor, with an IC₅₀ of 11.5 μM. Rhein-8-glucoside calcium has antibacterial effects^[1][2].

IC50: 11.5 μM (hPTP1B)^[1]

484.42

C₂₁H₁₆CaO₁₁

113443-70-2

大黄酸-8-O-β-D-葡萄糖苷

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li S, et, al. PTP1B inhibitors from Saussrurea lappa. J Asian Nat Prod Res. Apr-May 2006;8(3):281-6.  [Content Brief]

  [2]. Zhang Y, et, al. Effects of Rhein-8-O-β-D-glucopyranoside on the Biofilm Formation of Streptococcus mutans. Curr Microbiol. 2020 Oct 31.  [Content Brief]

  [3]. Zhang LS, et, al. Rhein-8-O-β-D-glucopyranoside inhibited high glucose-induced apoptosis of human mesangial cells by regulating the lincRNA ANRIL/let-7a/TGF-β1/Smad signaling pathway. Exp Ther Med. 2020 Apr;19(4):2871-2878.  [Content Brief]