2. Apoptosis
  3. RIP kinase
  4. RIPK1-IN-19

RIPK1-IN-19 是一种选择性的 RIPK1 抑制剂 (IC50=15 nM)。RIPK1-IN-19 对 RIPK2、RIPK3 和 RIPK4 无明显活性。RIPK1-IN-19 在 TNFα 诱导的全身炎症反应综合征 (SIRS) 模型和 Imiquimod (HY-B0180) 诱导的银屑病模型中显示出强大的保护活性。RIPK1-IN-19 可用于炎症与免疫系统疾病的研究。

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RIPK1-IN-19

RIPK1-IN-19 Chemical Structure

CAS No. : 2763831-43-0

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RIPK1-IN-19 相关抗体

Top Publications Citing Use of Products

查看 RIP kinase 亚型特异性产品:

查看所有亚型
RIPK1 RIPK2 RIPK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RIPK1-IN-19 is a selective RIPK1 inhibitor (IC50=15 nM). RIPK1-IN-19 does not show obvious activity against RIPK2, RIPK3, and RIPK4. RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ)-induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases[1].

IC50 & Target[1]

RIPK1

15 nM (IC50)

体外研究
(In Vitro)

RIPK1-IN-19 (compound 10b) 有效保护 U937、J774A.1 和 L929 细胞免于坏死性凋亡，EC50 值分别为 47.8、75.3 和 10.2 pM[1]。
RIPK1-IN-19 (0.03-300 nM) 可抑制 RIPK1 及其下游信号蛋白 RIPK3 和 MLKL 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RIPK1-IN-19 相关抗体:
体内研究
(In Vivo)

RIPK1-IN-19 (compound 10b) (10 mg/kg；口服；一次) 在 TNFα 诱发的全身炎症反应综合征 (SIRS) 模型中提供强大的保护作用[1]。
局部施用 RIPK1-IN-19 (10%) 可通过减少 Imiquimod 诱发的银屑病模型中的皮肤脱屑和增厚来改善银屑病样皮肤症状[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (aged 6-8 weeks, ~20 g)[1]
Dosage: 10 mg/kg
Administration: p.o.; for around 15 min and then challenged with mouse TNF-α (450 μg/kg)
Result: Dramatically increased the survival rate of TNFα-treated mice.
Strongly reduced TNFα-induced temperature loss in mice.
Significantly reduced the contents of proinflammatory cytokines including IL-1β and IL-6.
分子量

496.54

Formula

C28H25FN6O2
CAS 号
性状

固体

颜色

Light brown to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (286 KB) HNMR (326 KB)

产品使用指南 (1538 KB)
参考文献

RIPK1-IN-19 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK1-IN-192763831-43-0RIP kinaseReceptor-interacting protein kinasesRIPKinflammationTNFαSIRSImiquimodIMQpsoriasisimmuneInhibitorinhibitorinhibit

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