(S)-DMAPT  (Synonyms: (S)-Dimethylamino Parthenolide)

(S)-DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active NF-κB inhibitor, with a LD₅₀ of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect^[1].

DMAPT 处理降低了组成型 NF-κB 结合活性，抑制了 PC-3 和 DU145 细胞的细胞增殖和活力^[2]。
5 和 4 μM DMAPT 处理 PC-3 和 DU145 细胞，分别将 PC-3 前列腺癌细胞的群体倍增时间从 23.0 ± 5.0 小时增加到 42.0 ± 3.0 小时，将 DU145 细胞的群体倍增时间从 20.4 ± 2.2 小时增加到 72.5 ± 24.8 小时^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

用 DMAPT (100 mg/kg，每天口服管饲法，持续 7 天) 处理可提高 PC-3 肿瘤异种移植物对 X 射线的敏感性^[2]。
DMAPT (100 mg/kg，从出生后 42 天到 300 天，每周口服管饲三次) 处理可减缓 TRAMP 小鼠的正常肿瘤发展，将可触及前列腺肿瘤的时间延长 20%^[3]。
DMAPT 进一步在 TRAMP 小鼠^[3]中，肺组织中的转移面积低于水载体处理组 (0.10% ± 0.15 SD，减少 92%，p=0.0028)。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

293.40

C₁₇H₂₇NO₃

870677-05-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Neelakantan S, et al. Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1). Bioorg Med Chem Lett. 2009 Aug 1;19(15):4346-9.  [Content Brief]

  [2]. Mendonca MS, et al. DMAPT inhibits NF-κB activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo. Free Radic Biol Med. 2017 Nov;112:318-326.  [Content Brief]

  [3]. Morel KL, et al. Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide. Clin Exp Metastasis. 2018 Oct;35(7):649-661.  [Content Brief]