1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-Me-C10-NH2

(S,R,S)-AHPC-Me-C10-NH2 

目录号: HY-130847
产品使用指南

(S,R,S)-AHPC-Me-C5-COOH 是一种合成的 E3 连接酶配体结合物,它结合了 VHL 配体和连接子。(S,R,S)-AHPC-Me-C5-COOH 可用于 PROTAC MS432 (HY-130602)。

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(S,R,S)-AHPC-Me-C10-NH2 Chemical Structure

(S,R,S)-AHPC-Me-C10-NH2 Chemical Structure

CAS No. : 2376139-52-3

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Description

(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432 (HY-130602)[1].

IC50 & Target

VHL

 

In Vitro

MS432 is a first-in-class and highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2[1].

Molecular Weight

627.88

Formula

C₃₄H₅₃N₅O₄S

CAS No.

2376139-52-3

SMILES

O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCCCCCCCCCN)=O)C(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(S,R,S)-AHPC-Me-C10-NH2E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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产品名称:
(S,R,S)-AHPC-Me-C10-NH2
目录号:
HY-130847
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