2. Neuronal Signaling
  3. Sigma Receptor
  4. S1R agonist 2

S1R agonist 2 (Compound 8b) 是一种选择性 S1R 激动剂，对 S1R 和 S2R 的 Ki 分别为 1.1 nM 和 88 nM。S1R agonist 2 对 ROS 和 NMDA 诱导的神经毒性具有神经保护作用。

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S1R agonist 2 Chemical Structure

S1R agonist 2 Chemical Structure

CAS No. : 150085-21-5

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Other Forms of S1R agonist 2:

S1R agonist 2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].

IC50 & Target[1]

Sigma 1 Receptor

1.1 nM (Ki)

Sigma 2 Receptor

88 nM (Ki)

体外研究
(In Vitro)

S1R agonist 2 (Compound 8b; 0.1-5 μM) 均能显著增加神经生长因子 (NGF) 诱导的神经突生长，且呈剂量依赖性[1]。
S1R agonist 2 (24 h) 在 SHSY5Y 细胞中浓度为 1 μM 时对 Rotenone (HY-B1756) 诱导的细胞损伤有显著的抑制作用[1]。
S1R agonist 2 (0.1-5 μM; 24 h) 在 SHSY5Y 细胞中对 NMDA 刺激有神经保护作用[1]。
S1R agonist 2 (0-10 μM; 24-72 h) 对 A549、LoVo 和 Panc-1 细胞无细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

S1R agonist 2 相关抗体:
体内研究
(In Vivo)

S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) 在 10 μM 浓度下不诱导胚胎死亡 (100%存活胚胎)，但在最高剂量 (50 μM) 下诱导所有胚胎死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

309.45

Formula

C21H27NO
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (187 KB) HNMR (311 KB)

产品使用指南 (1538 KB)
参考文献

S1R agonist 2 相关分类

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Keywords:

S1R agonist 2150085-21-5Sigma ReceptorSHSY5YPC12Inhibitorinhibitorinhibit

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S1R agonist 2
目录号：
HY-149804
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