1. Anti-infection
  2. SARS-CoV Virus Protease
  3. SARS-CoV-2 Mpro-IN-4

SARS-CoV-2 Mpro-IN-4 是主要蛋白酶 (MPro) 和组织蛋白酶 L (CatL) 的双重抑制剂,IC50s 分别为 900 nM 和 60 nM。SARS-CoV-2 Mpro-IN-4 对 SARS-CoV2 具有抗病毒活性。SARS-CoV-2 Mpro-IN-4 在表达 hACE2 的 A549 细胞中可阻断 SARS-CoV2 的复制,IC50 值为 8.2 nM。

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SARS-CoV-2 Mpro-IN-4 Chemical Structure

SARS-CoV-2 Mpro-IN-4 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SARS-CoV-2 Mpro-IN-4 is a dual Inhibitor of Main Protease (MPro) and Cathepsin L (CatL), with IC50s of 900 nM and 60 nM respectively. SARS-CoV-2 Mpro-IN-4 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-4 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 value of 8.2 nM[1].

IC50 & Target

MPro/CatL[1]

体外研究
(In Vitro)

SARS-CoV-2 Mpro-IN-4 (SM141) blocks SARS-CoV2 replication in A549-hACE2 cells with IC50 value of 8.2 nM[1].
SARS-CoV-2 Mpro-IN-4 (50 μM, 24 h) does not cause any notable cytotoxicity in A549-hACE2 cells[1].
SARS-CoV-2 Mpro-IN-4 inhibits OC-43 virus mRNA expression A549 cells[1].
SARS-CoV-2 Mpro-IN-4 inhibits SARS-CoV2 infection by inhibiting both MPro and CatL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SARS-CoV-2 Mpro-IN-4 (SM141) (10 mg/kg for i.n. or 25 mg/kg for i.p.) protects K18-ACE2 mice from SARS-CoV2-induced weight loss and lethality[1].
SARS-CoV-2 Mpro-IN-4 (3 mg/kg, i.v.) shows a short half-life of 0.8 h and high clearance of 72 mL/min/kg in in male C57Bl/6 mice[1].
SARS-CoV-2 Mpro-IN-4 (10 mg/kg, p.o.) shows oral bioavailability of 5%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: K18-hACE2 transgenic mice[1]
Dosage: 10 mg/kg (i.n.) or 25 mg/kg (i.p.)
Administration: Intranasal inhalation (i.n.), once daily for 3 days, prior to the infection; or Intraperitoneal injection (i.p.), twice daily for 5 days, postinfection administration.
Result: Prevented weight loss and prolonged survival.
分子量

534.65

Formula

C30H38N4O5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

SARS-CoV-2 Mpro-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SARS-CoV-2 Mpro-IN-4
目录号:
HY-151900
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