2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Kinesin Apoptosis
  4. SCH 2047069

SCH 2047069 (MK-8267) 是一种口服有效且能透过血脑屏障的纺锤体驱动蛋白 (KSP) 抑制剂 (Kd: 0.5 nM)。SCH 2047069 对 KSP ATP 酶的 IC50 ≤ 5 nM。SCH 2047069 具有广谱的抗肿瘤活性。SCH 2047069 可诱导肿瘤细胞有丝分裂停滞和凋亡 (apoptosis)。SCH 2047069 可用于卵巢癌、结肠癌、胶质母细胞瘤、淋巴瘤等肿瘤的研究。

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SCH 2047069

SCH 2047069 Chemical Structure

CAS No. : 1146209-50-8

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SCH 2047069 相关抗体

Top Publications Citing Use of Products

查看 Kinesin 亚型特异性产品:

查看所有亚型
Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (Kd: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC50 value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma[1][2].

分子量

439.43

Formula

C20H17F4N3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SCH 2047069 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH 20470691146209-50-8MK-8267SCH2047069SCH-2047069MK8267MK 8267KinesinApoptosisA2780Colo-205HCT-116U373EOL-1DoHH2Inhibitorinhibitorinhibit

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