SDH-IN-25 

SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC₅₀ = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control^[1].

SDH-IN-25 (Compound 7IIj) (0-20 mg/L) 对八种植物病原菌株表现出优异的广谱杀菌效果，包括 R. solani (EC₅₀ = 0.179 mg/L), P. piricola (EC₅₀ = 0.301 mg/L), S. sclerotiorum (EC₅₀ = 3.47 mg/L), V. mali (EC₅₀ = 0.789 mg/L), F. graminearum (EC₅₀ = 6.29 mg/L), B. cinerea (EC₅₀ = 0.647 mg/L), P. capsici (EC₅₀ = 5.78 mg/L), 和 G. graminis (EC₅₀ = 0.549 mg/L)^[1]。
SDH-IN-25 (5-20 mg/L，1-9 小时) 可抑制R. solani的呼吸代谢^[1]。
SDH-IN-25 (0-20 mg/L，2 天) 表现出优异的 R. solani SDH 抑制活性，IC₅₀ 值为 4.82 mg/L^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SDH-IN-25 (Compound 7IIj) (200 mg/L，24 小时) 对感染 V. mali 的苹果嫩枝表现出显著的保护作用，防治效果达 69.7%^[1]。
SDH-IN-25 (100 mg/L，10 分钟) 对感染稻瘟病菌的离体水稻叶片和感染稻瘟病菌的水稻植株均显示出显著的防治效果 (防效分别是 88.7% 和 69.8%)，且对水稻的安全性已得到验证^[1]。
SDH-IN-25 (1 mg/L，72 小时) 会导致R. solani菌丝生长异常，表现为菌丝表面干燥、塌陷和皱缩^[1]。
SDH-IN-25 (0.179 mg/L) 导致菌丝中的 ROS 水平升高和 MMP 破坏^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

486.14

C₁₉H₁₅BrCl₂N₂O₄

3052432-15-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang FY, Xu D, He HW, Lin GT, Zhou H, Liu X, Xu G. Discovery of α-Methylene-γ-Butyrolactone Derivatives with Hydrazide Moieties as Novel Fungicidal Agents. J Agric Food Chem. 2025 Apr 23;73(16):9521-9532.  [Content Brief]