糖苷内切酶 D
Endo-β-N-acetylglucosaminidase D (Endo D) 能够从肺炎链球菌 (Streptococcus pneumoniae) 中分离得到。在连续去除 N-聚糖中的唾液酸、半乳糖和内部 GlcNAc 残基后，Endo-β-N-acetylglucosaminidase D 可水解完整 IgG 抗体的 Fc N-聚糖。Endo-β-N-acetylglucosaminidase D 具有以糖恶唑啉为供体底物的转糖基活性<sup>[1]sup>。
Endo SH 是一种 Endo S (来源于 Streptococcus pyogenes) 和 Endo H (来源于 Streptomyces plicatus) 的融合蛋白，表达自大肠杆菌。Endo SH 可对 N-糖蛋白中的高甘露糖，复杂型和某些杂合型寡聚糖的壳二糖核心结构进行切割，去除糖蛋白中的 N-连接高甘露糖，可完全替代 Endo S 和 Endo H。
A sub-library of GPCR Library designed for the discovery of novel allosteric ligands. Allosteric GPCRs Library is a utile starting point for the drug discovery in the field of allosteric GPCR modulators.
Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.
The PPI Library comprises molecules of various sizes, frameworks, and shapes ranging from fragment-like entities to macrocyclic derivatives designed as secondary structure mimetics or as epitope mimetics. The designs cover β-turn / loop mimetics and α-helix mimetics. Since helices present at the interface in 62% of all protein-protein interactions. This library focused on designs including mimics with the substitution geometry of an a-helices, as well as designs that mimic the location of “hot-spot” side chains in helix-mediated PPIs.
The Chinese National Compound Library (CNCL) composes 1.4 million compounds possessing diversified structures. Coupled with this library will be advanced sample handling, information management and quality control systems. Most compounds in the library are drug-like, conforming to “Lipinski’s Rule of Five”, such as MW < 500, logP < 5, Hydrogen Bond Donors < 5.
从传统中药到现代抗生素的发现，天然产物在药物开发进程中发挥了重要作用。对所有 FDA 批准的药物评估显示，天然产品及其类似物占所有已批准药物的三分之一以上。其中近一半来自哺乳动物，四分之一来自微生物，四分之一来自植物。随着时间的推移，已上市药物中微生物天然产物和天然产物类似物的占比增加了。天然产物在药物开发中具有天然的优势，可以作为药物发现的先导化合物，用于药物鉴定和机制研究。
ENDO VIII 蛋白
ENDO VIII 蛋白对于基因重组、DNA 修复和复制至关重要，执行配对和链转移等基本活动。它有助于维持基因组完整性，并通过与 dda 和基因 32 蛋白相互作用形成复杂的分子网络。作为 RecA 家族的成员，ENDO VIII 蛋白强调了其在与 DNA 动力学和基因组稳定性相关的更广泛细胞机制中的重要性。ENDO VIII Protein, E. coli (His) 是重组的 ENDO VIII 蛋白，由 E. coli 表达，带有 N-6*His 标签。ENDO VIII Protein, E. coli (His) ，分子量约为 ~44 kDa。
ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1
Dxd, OQM5SD32BQ, UNII-OQM5SD32BQ, Exatecan derivative, Exatecan derivative for ADC
ELISA
Species independent
DXd Antibody (YA897) is an unconjugated, mouse-derived, anti-DXd (YA897) monoclonal antibody. DXd Antibody (YA897) can be used for: ELISA expriments in species-independent background without labeling.
MRC2 Antibody (YA2364) is a non-conjugated IgG antibody, targeting MRC2, with a predicted molecular weight of 167 kDa (observed band size: 190 kDa). MRC2 Antibody (YA2364) can be used for WB experiment in human background.
CD146 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 72 kDa, targeting to CD146. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Rat.
RF1 Antibody (YA4125) is a mouse-derived and non-conjugated IgG1 antibody, targeting to RF1. It can be applicated for WB, FC, ELISA assays, in the background of human.
Endo G Antibody (YA1529) is a non-conjugated IgG antibody, targeting Endo G, with a predicted molecular weight of 33 kDa (observed band size: 30 kDa). Endo G Antibody (YA1529) can be used for WB experiment in human, mouse, rat background.
CD146 Antibody (YA5482) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD146. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.
CD146 Antibody (YA6102) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD146. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.
Synaptosomal-associated protein 25; SNAP-25; super protein; sup; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP
WB, ICC/IF, IP
Human, Mouse, Rat
SNAP25 Antibody (YA1412) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1412), targeting SNAP25, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). SNAP25 Antibody (YA1412) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
MRP4; MOATB; MOAT-B; EST170205; ABCC 4 antibody;
ABCC4 antibody;
ATP binding cassette sub family C (CFTR/MRP) member 4 antibody;
ATP binding cassette sub family C member 4 antibody
IHC-P, FC, ELISA
Human
MRP4 Antibody (YA3530) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ABCC4. It can be applicated for IHC-P, FC, ELISA assays, in the background of human.
CARD2; CK 8; CK-8; CK8; CYK8; CYKER; Cytokeratin endo A; CytokeRatin-8; DreK8; endoA; K2C8; K2C8_HUMAN; K8; KeRatin 8; KeRatin type II cytoskeletal 8; KeRatin, type II cytoskeletal 8; KeRatin-8; KO; Krt 2.8; KRT8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; Type-II keRatin Kb8; CK 18; CK-18; CK18; CYK18; Cytokeratin 18; Cytokeratin endo B; CytokeRatin-18; K 18; K18; K1C18_HUMAN; KA18; KeRatin 18; KeRatin 18, type I; KeRatin D; keRatin, type I cytoskeletal 18; KeRatin-18; Krt18
IHC-P, WB, ICC/IF, ELISA
Human, Mouse, Rat
Cytokeratin 8/18 Antibody (YA5596) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Cytokeratin 8/18. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse, rat.
ABC42 antibody; Abcd1 antibody; ABCD1_HUMAN antibody; Adrenoleukodystrophy protein antibody; ALD antibody; Aldgh antibody; ALDP antibody; AMN antibody; ATP binding cassette, sub family D (ALD), member 1 antibody; ATP-binding cassette sub-family D member 1 antibody; ABC42 antibody; Abcd1 antibody; ABCD1_HUMAN antibody; Adrenoleukodystrophy protein antibody; ALD antibody; Aldgh antibody; ALDP antibody; AMN antibody; ATP binding cassette, sub family D (ALD), member 1 antibody; ATP-binding cassette sub-family D member 1 antibody; OTTHUMP00000025960 antibody; OTTMUSP00000019283 antibody; RGD1562128 antibody; RP23 373N8.2 antibody; X linked adrenoleukodystrophy (ALD) gene homolog antibody
ABCB5 P-gp; ATP binding cassette sub family B (MDR/TAP) member 5; P glycoprotein ABCB5
WB, ICC/IF
Human
ABCB5 Antibody (YA836) is a non-conjugated and Mouse origined monoclonal antibody about 139 kDa, targeting to ABCB5 (8D2). It can be used for WB,ICC/IF assays with tag free, in the background of Human.
ABCB5; ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5
WB, IHC-P, ICC/IF,
Human
ABCB5 Antibody (YA5354) is a mouse-derived and non-conjugated monoclonal antibody, targeting to ABCB5. It can be applicated for WB, IHC-P, ICC/IF, assays, in the background of human.
ABC20; ABCB1; ATP binding cassette, sub family B(MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; PGY1.
IHC-P, IF-Tissue, IHC-F, WB
Human, Mouse, Rat
P Glycoprotein Antibody (YA6354) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P Glycoprotein. It can be applicated for IHC-P, IF-Tissue, IHC-F, WB assays, in the background of human, mouse, rat.
CARD2; CK 8; CK-8; CK8; CYK8; CYKER; Cytokeratin endo A; Cytokeratin-8; DreK8; endoA; K2C8; K2C8_HUMAN; K8; Keratin 8; Keratin type II cytoskeletal 8; Keratin, type II cytoskeletal 8; Keratin-8; KO; Krt 2.8; KRT8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; Type-II keratin Kb8
WB, IHC-P, ICC/IF, IP, ELISA
Human, Mouse, Rat
Cytokeratin 8 Antibody (YA6196) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 8. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.
ABC20; ABCB1; ATP binding cassette, sub family B; MDR/TAP; , member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1
IHC-P, WB, ICC/IF, ELISA
Human, Mouse,
P Glycoprotein Antibody (YA5626) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MDR1. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse.
ABC20; ABCB1; ATP binding cassette, sub family B; MDR/TAP; , member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1
IHC-P, ELISA
Human, Mouse,
P Glycoprotein Antibody (YA5747) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MDR1. It can be applicated for IHC-P, ELISA assays, in the background of human, mouse.
ABC20; ABCB1; ATP binding cassette, sub family B; MDR/TAP; , member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1
WB, IHC-P, ICC/IF, IP, ELISA
Human
P Glycoprotein Antibody (YA6028) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MDR1. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human.
p-pg; PGP; ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243
WB
Human
P Glycoprotein Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 141 kDa, targeting to P Glycoprotein. It can be used for WB assays with tag free, in the background of Human.
ABCG2; ABCP; BCRP; BCRP1; MXR; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; CD antigen CD338
WB, IHC-P, ICC/IF, FC, ELISA
Human, Mouse, Monkey
ABCG2 Antibody (YA4719) is a mouse-derived and non-conjugated monoclonal antibody, targeting to ABCG2. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, monkey.
ABC30 antibody;
abcC2 antibody;
ATP binding cassette sub family C (CFTR/MRP) member 2 antibody;
ATP binding cassette subfamily C member 2 antibody;
ATP-binding cassette sub-family C member 2 antibody;
Canalicular multidrug resistance protein antibody;
Canalicular multispecific organic anion transporter 1 antibody;
CMOAT antibody;
CMOAT1 antibody;
cMRP antibody;
DJS antibody;
KIAA1010 antibody;
MRP 2 antibody;
MRP2_HUMAN antibody;
Multidrug resistance associated protein 2 antibody;
Multidrug resistance-associated protein 2 antibody;
WB, ICC/IF, FC
Human
MRP2/ABCC2 Antibody is an unconjugated, approximately 174 kDa, rabbit-derived, anti-MRP2/ABCC2 monoclonal antibody. MRP2/ABCC2 Antibody can be used for: WB, ICC/IF, FC expriments in human background without labeling.
ABC 35 antibody
ABC35 antibody
ABCC 7 antibody
ABCC7 antibody
ATP binding cassette sub family C member 7 antibody;
cAMP dependent chloride channel antibody;
cAMP-dependent chloride channel antibody;
CF antibody;
CFTR antibody;
CFTR/MRP antibody;
CFTR_HUMAN antibody;
Channel conductance controlling ATPase antibody;
Channel conductance-controlling ATPase antibody;
Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7) antibody;
Cystic fibrosis transmembrane conductance regulator antibody;
Cystic Fibrosis Transmembrane Regulator antibody;
dJ760C5.1 antibody;
MRP 7 antibody;
MRP7 antibody;
TNR CFTR antibody
WB, IP
Human
CFTR Antibody(YA3569) is a rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to CFTR. It can be applicated for WB, IP assays, in the background of human.
