1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor 5-HT Receptor
  3. SGB-1534 hydrochloride

SGB-1534 (hydrochloride) 是一种建议口服活性的、选择性的竞争性alpha 1-adrenoceptor5-HT2 receptor 拮抗剂。SGB-1534 (hydrochloride) 可抑制血管收缩并降低血压。SGB-1534 (hydrochloride) 可用于心血管疾病的研究,如高血压。

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SGB-1534 hydrochloride

SGB-1534 hydrochloride Chemical Structure

CAS No. : 88068-72-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SGB-1534 (hydrochloride) is an orally active, selective and competitive antagonist of the alpha 1-adrenoceptor and the 5-HT2 receptor. SGB-1534 (hydrochloride) can inhibit vasoconstriction and lower blood pressure. SGB-1534 (hydrochloride) can be used for the research of cardiovascular disease, such as hypertension[1][2].

IC50 & Target[1]

α1-adrenergic receptor

 

5-HT2 Receptor

 

体内研究
(In Vivo)

SGB-1534 (hydrochloride) (0.1-3 mg/kg,口服) 在清醒的自发性高血压大鼠 (SHR)、肾性高血压大鼠和 DOCA (HY-B1472) 盐诱导的高血压大鼠中均表现出强效且持久的降压作用,但仅轻微增加心率[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

416.90

Formula

C21H25ClN4O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SGB-1534 hydrochloride
目录号:
HY-106418A
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