2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. SHP244

SHP244 是一种靶向 SHP2 蛋白“门闩位点” (位点 2) 的变构抑制剂，其对于 SHP2WT 的 IC50 值为 60 μM。SHP244 单独处理对 p-ERK 水平无显著影响，但与 RMC-4550 (HY-116009) (“隧道位点”位点 1 抑制剂) 连用后可降低 p-ERK，且抑制 p-ERK 反弹，降低耐药性。SHP244 可用于研究 FGFR 驱动癌症中的耐药性。

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SHP244

SHP244 Chemical Structure

CAS No. : 902891-37-6

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SHP244 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

SHP244 is a conformational inhibitor targeting the "latch allosteric site" (site 2) of the SHP2 protein with an IC50 value for SHP2WT of 60 μM. SHP244 has no significant effect on the level of p-ERK alone. SHP244 combined with RMC-4550 (HY-116009) ("tunnel site" site 1 inhibitor) can reduce p-ERK and inhibit the rebound of p-ERK, thereby reducing drug resistance. SHP244 can be used to study drug resistance in FGFR-driven cancers[1].

分子量

432.86

Formula

C23H17ClN4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SHP244 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHP244902891-37-6SHP 244SHP-244SHP2Src homology phosphatase 2PTPN11binding modelsdrug discoveryprotein tyrosine phosphataseSHP2 inhibitorsstructural landscapeInhibitorinhibitorinhibit

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