2. Anti-infection
  3. SARS-CoV
  4. SIMR3030

SIMR3030 是一种有效的 SARS-CoV-2 PLpro 抑制剂，IC50 值为 0.0399 µg/mL。SIMR3030 显示出抗病毒活性。SIMR3030 降低 SARS-CoV spike、ORF1b、IFN-α、IL-6 mRNA 表达。SIMR3030 在小鼠中表现出较好的安全性。

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SIMR3030

SIMR3030 Chemical Structure

CAS No. : 2708270-99-7

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SIMR3030 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice[1].

IC50 & Target

IC50: 0.0399 µg/mL (SARS-CoV-2 PLpro)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero C1008 CC50
55.63 μg/mL
Compound: SIMR3030
Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by crystal violet staining based analysis
Cytotoxicity against African green monkey Vero E6 cells measured after 72 hrs by crystal violet staining based analysis
[PMID: 37075625]
体外研究
(In Vitro)

SIMR3030 (0-100 µg/mL) 显示抗病毒活性，对 SARS-CoV-2 和 MERS-CoV 的 IC50 值分别为 12.1、6.206 μg/mL[1]。
SIMR3030 (20 µg/mL; 1, 6, 12 h) 降低 Caco-2 细胞中的 SARS-CoV spike、ORF1b、IFN-α、IL-6 mRNA 表达水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SIMR3030 相关抗体:

RT-PCR[1]

Cell Line: Caco-2 cells (SARS-CoV-2 RNA infected)
Concentration: 20 μg/mL
Incubation Time: 1, 6, 12 h
Result: Decreased SARS-CoV spike and ORF1b mRNA expression levels, reduced the mRNA expression of IFN-α at 1 and 3 h , IL-6 and OAS1 at 1, 3 and 12 h.
体内研究
(In Vivo)

SIMR3030 (25、50、100 mg/kg；I.p.；每日一次，持续 14 天) 在实验小鼠模型中表现出较好的安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-25 g, adult female Balb/c mice[1]
Dosage: 25, 50, 100 mg/kg
Administration: I.p.; daily for 14 days
Result: Showed no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days, no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days.
分子量

427.54

Formula

C27H29N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SIMR3030 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIMR30302708270-99-7SIMR 3030SIMR-3030SARS-CoVSARS coronavirusCaco-2 cellsantiviralSARS-CoV spikeORF1bIFN-αIL-6Inhibitorinhibitorinhibit

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产品名称：
SIMR3030
目录号：
HY-149940
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