1. Cell Cycle/DNA Damage Epigenetics
  2. PARP
  3. SK-575-NEG

SK-575-NEG (化合物 28)是 SK-575 的甲基化对应物,由 SK-575 中哌啶-2,6-二酮的氨基甲基化合成,作为对照化合物。SK-575-NEG 与 PARP1 强结合,其 IC50 值为 2.64 nM。当浓度达到 1 μM 时,SK-575-NEG 对 MDA-MB-436 和 Capan-1 细胞的 PARP1 降解完全无效。

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SK-575-NEG Chemical Structure

SK-575-NEG Chemical Structure

CAS No. : 2523017-04-9

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规格 价格 是否有货 数量
5 mg ¥8078
3 - 4 周
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM[1].

IC50 & Target

PARP-1

2.64 nM (IC50)

分子量

891.00

Formula

C48H55FN8O8

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

SK-575-NEG 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SK-575-NEG
目录号:
HY-147101
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