1. Apoptosis
  2. TNF Receptor
  3. SPD304 dihydrochloride

SPD304 dihydrochloride 

目录号: HY-111255A
产品使用指南

SPD304 dihydrochloride 是肿瘤坏死因子 α (TNF-α) 的选择性抑制剂,能够促进肿瘤坏死因子三聚体的分离,从而阻断其与受体间的相互作用。SPD304 体外抑制肿瘤坏死因子 α 和受体 1 间结合的 IC50 值为 22 µM。

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SPD304 dihydrochloride Chemical Structure

SPD304 dihydrochloride Chemical Structure

CAS No. : 1049741-03-8

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Description

SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2].

IC50 & Target

IC50: 22 µM (TNFα)[1].

In Vitro

SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p−RIP3 1.4−fold compared to GA alone, and promotes caspase 8 activation[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SPD304 cannot be used in vivo due to its high toxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

620.53

Formula

C₃₂H₃₄Cl₂F₃N₃O₂

CAS No.

1049741-03-8

SMILES

O=C1C(CN(C)CCN(C)CC2=CN(C3=CC=CC(C(F)(F)F)=C3)C4=C2C=CC=C4)=COC5=CC(C)=C(C)C=C15.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

SPD304SPD 304SPD-304TNF ReceptorTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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产品名称:
SPD304 dihydrochloride
目录号:
HY-111255A
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