2. Vitamin D Related/Nuclear Receptor Cytoskeleton Cell Cycle/DNA Damage Apoptosis
  3. Estrogen Receptor/ERR Microtubule/Tubulin Apoptosis
  4. STX140

STX140 是一种具有口服活性的微管 (microtubule) 破坏剂。STX140 诱导激素非依赖性 PC-3 前列腺细胞系凋亡 (apoptosis)。STX140 具有抗血管生成和抗肿瘤活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

STX140

STX140 Chemical Structure

CAS No. : 401600-86-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2108
3 - 4 周
5 mg 询价 3 - 4 周
10 mg 询价 3 - 4 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

STX140 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 GI50
0.083 μM
Compound: 21, 2-MeOE2bisMATE
Growth inhibition of human DU145 cell line
Growth inhibition of human DU145 cell line
[PMID: 17181151]
DU-145 GI50
0.34 μM
Compound: 2
Antiproliferative activity against human DU145 cells after 96 hrs by WST-1 assay
Antiproliferative activity against human DU145 cells after 96 hrs by WST-1 assay
[PMID: 20225862]
DU-145 GI50
0.34 μM
Compound: 3
Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay
Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay
[PMID: 17696419]
DU-145 GI50
0.34 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against human DU145 cells
Antiproliferative activity against human DU145 cells
[PMID: 18260615]
HCT-116 GI50
0.045 μM
Compound: 2
Antiproliferative activity against human HCT116 cells after 96 hrs by WST-1 assay
Antiproliferative activity against human HCT116 cells after 96 hrs by WST-1 assay
[PMID: 20225862]
HCT-116 GI50
0.045 μM
Compound: 21, 2-MeOE2bisMATE
Growth inhibition of human HCT116 cell line
Growth inhibition of human HCT116 cell line
[PMID: 17181151]
HCT-116 GI50
0.045 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against human HCT116 cells
Antiproliferative activity against human HCT116 cells
[PMID: 18260615]
HOP-62 GI50
0.051 μM
Compound: 2
Antiproliferative activity against human HOP62 cells after 96 hrs by WST-1 assay
Antiproliferative activity against human HOP62 cells after 96 hrs by WST-1 assay
[PMID: 20225862]
HOP-62 GI50
0.051 μM
Compound: 21, 2-MeOE2bisMATE
Growth inhibition of human HOP62 cell line
Growth inhibition of human HOP62 cell line
[PMID: 17181151]
HOP-62 GI50
0.051 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against human HOP62 cells
Antiproliferative activity against human HOP62 cells
[PMID: 18260615]
HUVEC IC50
0.13 μM
Compound: 21, 2-MeOE2bisMATE
Antiangiogenic activity assessed as inhibition of cord formation in HUVEC
Antiangiogenic activity assessed as inhibition of cord formation in HUVEC
[PMID: 17181151]
HUVEC IC50
0.4 μM
Compound: 21, 2-MeOE2bisMATE
Antiangiogenic activity in HUVEC by chemotaxis assay
Antiangiogenic activity in HUVEC by chemotaxis assay
[PMID: 17181151]
HUVEC IC50
0.7 μM
Compound: 21, 2-MeOE2bisMATE
Antiangiogenic activity assessed as growth inhibition in HUVEC
Antiangiogenic activity assessed as growth inhibition in HUVEC
[PMID: 17181151]
HUVEC IC50
44 nM
Compound: 3, 2-MeO2bisMATE
Antiangiogenic activity against HUVEC cells assessed as inhibition of proliferation
Antiangiogenic activity against HUVEC cells assessed as inhibition of proliferation
[PMID: 18260615]
MCF7 GI50
0.25 μM
Compound: 21, 2-MeOE2bisMATE
Antiproliferative activity against human MCF7 cell line
Antiproliferative activity against human MCF7 cell line
[PMID: 17181151]
MCF7 GI50
0.25 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against estrogen receptor positive human MCF7 cells
Antiproliferative activity against estrogen receptor positive human MCF7 cells
[PMID: 18260615]
MCF7 IC50
0.25 μM
Compound: 15
Antiproliferative activity against estrogen receptor-positive human MCF7 cells
Antiproliferative activity against estrogen receptor-positive human MCF7 cells
[PMID: 31255926]
MDA-MB-231 ED50
10 mg/kg
Compound: 43
Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered daily
Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered daily
[PMID: 25992880]
MDA-MB-231 ED50
20 mg/kg
Compound: 43
Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered thrice weekly
Antitumor activity against human MDA-MB-231 cells xenografted in MF1 mouse administered thrice weekly
[PMID: 25992880]
MDA-MB-231 GI50
0.28 μM
Compound: 2
Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST-1 assay
Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST-1 assay
[PMID: 20225862]
MDA-MB-231 GI50
0.28 μM
Compound: 3
Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST1 assay
Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by WST1 assay
[PMID: 17696419]
MDA-MB-231 GI50
0.28 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells
Antiproliferative activity against estrogen receptor negative human MDA-MB-231 cells
[PMID: 18260615]
MDA-MB-231 IC50
0.29 μM
Compound: 15
Antiproliferative activity against estrogen receptor-negative human MDA-MB-231 cells
Antiproliferative activity against estrogen receptor-negative human MDA-MB-231 cells
[PMID: 31255926]
MDA-MB-435 GI50
< 0.01 μM
Compound: 21, 2-MeOE2bisMATE
Growth inhibition of human MDA-MB-435 cell line
Growth inhibition of human MDA-MB-435 cell line
[PMID: 17181151]
MDA-MB-435 GI50
< 0.01 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against human MDA-MB-435 cells
Antiproliferative activity against human MDA-MB-435 cells
[PMID: 18260615]
OVCAR-3 GI50
< 0.01 μM
Compound: 2
Antiproliferative activity against human OVCAR-3 cells after 96 hrs by WST-1 assay
Antiproliferative activity against human OVCAR-3 cells after 96 hrs by WST-1 assay
[PMID: 20225862]
OVCAR-3 GI50
< 0.01 μM
Compound: 21, 2-MeOE2bisMATE
Growth inhibition of human OVCAR-3 cell line
Growth inhibition of human OVCAR-3 cell line
[PMID: 17181151]
OVCAR-3 GI50
< 0.01 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against human OVCAR-3 cells
Antiproliferative activity against human OVCAR-3 cells
[PMID: 18260615]
SF-539 GI50
0.036 μM
Compound: 2
Antiproliferative activity against human SF539 cells after 96 hrs by WST-1 assay
Antiproliferative activity against human SF539 cells after 96 hrs by WST-1 assay
[PMID: 20225862]
SF-539 GI50
0.036 μM
Compound: 21, 2-MeOE2bisMATE
Growth inhibition of human SF539 cell line
Growth inhibition of human SF539 cell line
[PMID: 17181151]
SF-539 GI50
0.036 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against human SF539 cells at
Antiproliferative activity against human SF539 cells at
[PMID: 18260615]
SN12C GI50
0.126 μM
Compound: 2
Antiproliferative activity against human SN12C cells after 96 hrs by WST-1 assay
Antiproliferative activity against human SN12C cells after 96 hrs by WST-1 assay
[PMID: 20225862]
SN12C GI50
0.126 μM
Compound: 21, 2-MeOE2bisMATE
Growth inhibition of human SN12-C cell line
Growth inhibition of human SN12-C cell line
[PMID: 17181151]
SN12C GI50
0.126 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against human SN12-C cells
Antiproliferative activity against human SN12-C cells
[PMID: 18260615]
UACC-62 GI50
< 0.01 μM
Compound: 2
Antiproliferative activity against human UACC62 cells after 96 hrs by WST-1 assay
Antiproliferative activity against human UACC62 cells after 96 hrs by WST-1 assay
[PMID: 20225862]
UACC-62 GI50
< 0.01 μM
Compound: 21, 2-MeOE2bisMATE
Growth inhibition of human UACC62 cell line
Growth inhibition of human UACC62 cell line
[PMID: 17181151]
UACC-62 GI50
< 0.01 μM
Compound: 3, 2-MeO2bisMATE
Antiproliferative activity against human UACC62 cells
Antiproliferative activity against human UACC62 cells
[PMID: 18260615]
体外研究
(In Vitro)

STX140 是前列腺和乳腺癌细胞系中细胞增殖的强效抑制剂，对 PC-3、MDA-MB-231、LNCaP、MCF-7、A2780 和 HUVEC 的 IC50 值分别为 270 nM、290 nM、260 nM、250 nM、280 nM 和 44 nM[1]。
STX140 (0.5 μM; 24 h) 可强效诱导细胞周期停滞。 STX140 诱导激素非依赖性 PC-3 前列腺细胞系凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STX140 相关抗体:

Cell Cycle Analysis[1]

Cell Line: PC-3 cells
Concentration: 0.5 μM
Incubation Time: 24 h
Result: Potently induced cell cycle arrest with 71% of PC-3 cells being in G2/M after 24 h and 6% in G1.
体内研究
(In Vivo)

STX140（20 mg/kg；口服；每日一次；60 天）可导致肿瘤消退和完全缓解，在停止给药后仍可维持[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male MF-1 nu/nu mice injected with PC-3 cells[1]
Dosage: 20 mg/kg
Administration: p.o.; once daily; 60 days
Result: Led to tumour regression and complete responses.
分子量

460.56

Formula

C19H28N2O7S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STX140 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STX140401600-86-0STX 140STX-140Estrogen Receptor/ERRMicrotubule/TubulinApoptosismicrotubule disruptoranti-angiogenicanti-tumour activitiesapoptosisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
STX140
目录号：
HY-133222
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z